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Cardiovasc Diabetol:内脏肥胖指数越高,糖尿病肾病风险越高!

2022-03-07 Nebula MedSci原创

内脏肥胖指数越高,2型糖尿病患者发生糖尿病肾病的风险越高!

2型糖尿病占所有糖尿病的90%,已成为全球重要的公共健康问题。预计2030年时,全球约有3.66亿糖尿病患者。糖尿病血管并发症已成为2型糖尿病患者死亡的主要原因。此外,血管并发症严重影响患者的生活质量,给医疗保健系统带来沉重的经济负担。

多项横断面研究报告了内脏肥胖指数(VAI)与糖尿病并发症之间的相关性,但是,VAI对并发症进展的影响仍未完全明确。本研究旨在在中国人群队列中评估VAI及中国人VAI(CVAI)与糖尿病肾病和糖尿病视网膜病变的相关性。

研究流程

自2013年至2014年期间,从北京健康管理队列中共招募了8948位2型糖尿病患者,随访至2019年12月31日。通过尿白蛋白/肌酐比值和估计的肾小球滤过率诊断肾病;使用眼底照相诊断视网膜病变。

VAI和CVAI与糖尿病肾病风险的相关性

受试患者平均53.35岁(SD 14.66),其中6154位(68.8%)是男性。在中位随访4.82年期间,有467位受试者患上了糖尿病肾病,90位受试者患上了糖尿病视网膜病变。VAI和CVAI水平每增加1 SD与糖尿病肾病风险升高显著相关,校正的风险比(HR)分别是1.127(95% CI 1.050-1.210)和1.165(1.003-1.353)。相反,根据混杂因素校正后,VAI和CVAI水平与糖尿病视网膜病变风险无显著相关性。

根据VAI或CVAI预测糖尿病肾病风险的敏感性

总之,VAI和CVAI是2型糖尿病患者发展成糖尿病肾病的风险独立相关,但与发生视网膜病变的风险无明显相关性。

 

原始出处:

Wu, Z., Yu, S., Kang, X. et al. Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population. Cardiovasc Diabetol 21, 32 (2022). https://doi.org/10.1186/s12933-022-01464-1

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    2022-06-26 quxin068
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