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Pharm Biol:苋菜和菜籽油对肥胖患者中性粒细胞氧化代谢的影响

2020-06-24 MedSci原创 MedSci原创

苋菜油和低芥酸菜籽油经常使用。由于苋菜具有突出的营养价值,因此备受关注。苋菜油是高度不饱和脂肪的丰富来源,因此对于肥胖者而言,它可能是一种有价值的饮食替代品。假定活性氧(ROS)参与全身性炎症和氧化应

苋菜油和低芥酸菜籽油经常使用。由于苋菜具有突出的营养价值,因此备受关注。苋菜油是高度不饱和脂肪的丰富来源,因此对于肥胖者而言,它可能是一种有价值的饮食替代品。假定活性氧(ROS)参与全身性炎症和氧化应激。活化的多形核中性粒细胞(PMN)产生大量的活性氧。本研究调查了苋菜和低芥酸菜籽油补充剂对肥胖患者氧化代谢的影响。我们假设,由于苋菜籽油和低芥酸菜籽油具有降脂和抗氧化的作用,因此可以抵抗氧化应激。

 

我们测试了19名肥胖患者[体重指数(BMI)= 41.1±7.8 kg / m2,(平均±SD)]。该方案包括两个阶段:一个为期2周的磨合期和一个实验阶段-限热量饮食的低芥酸菜籽或苋菜油补充剂(20 mL / d),持续3周。中性粒细胞的氧化爆发由荧光强度(IF)表示。

 

结果显示,两组IF治疗结束时,氧化爆发均显著增加:(21.4±11.15 vs. 35.9±20.3;平均值±SD)p <0.05。接受低芥酸菜籽油治疗的中性粒细胞的IF水平(41.05±25.3)明显高于接受苋菜油的患者(28.4±11.8)的p <0.05。

 

综上所述,该研究结果表明,苋菜籽油在体内可影响嗜中性粒细胞中对氧化爆发活性。

 

原始出处:

 

Dominika Kanikowska, Alina Kanikowska, et al., Amaranth (Amaranthus Cruentus L.) and Canola (Brassica Napus L.) Oil Impact on the Oxidative Metabolism of Neutrophils in the Obese Patients. Pharm Biol. 2019 Dec;57(1):140-144. doi: 10.1080/13880209.2019.1569696.

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    2020-12-17 jj000001
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    2021-01-04 sunylz
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