Eur Heart J：维生素D缺乏在心血管疾病风险中的作用

2021-12-06 MedSci原创 MedSci原创

维生素D缺乏会增加心血管疾病的风险。该非线性孟德尔随机分析支持血清25-羟基维生素D浓度与CVD风险之间存在L形关联，这表明就心血管健康而言，改善维生素D状态对于缺乏的个体而言存在益处。

低维生素D状态与较高的心血管疾病(CVD)风险相关。尽管大多数现有的线性孟德尔随机化(MR)研究报告了维生素D与CVD风险之间并无相关性，但不能排除它们之间存在非线性效应。

近日，心血管领域权威杂志Eur Heart J上发表了一篇研究文章，研究人员的目的是应用非线性MR设计来探究血清25-羟基维生素D[25(OH)D]浓度与CVD风险之间的关联。

该研究的非线性MR分析是在英国生物银行中进行的，涉及44519例CVD病例和251269例对照者。血压(BP)和心脏成像衍生的表型被列为次要结局。研究人员使用35种已明确的全基因组显著变异检测了血清25(OH)D浓度。

研究人员还估计了由于纠正低维生素D状态而导致CVD发病率降低潜在效应。遗传预测的血清25(OH)D水平与CVD风险之间存在L形关联（非线性P=0.007），其中CVD风险最初随着浓度的增加而急剧下降，并稳定在50nmol/L左右。遗传预测的血清25(OH)D水平与收缩压(非线性P=0.03)和舒张压(非线性P=0.07)之间也存在类似的关联。研究人员未发现心脏成像表型相关性的证据（所有P=0.05）。研究人员预计血清25(OH)D水平低于50nmol/L会导致CVD发生率增加4.4%（95%置信区间为1.8-7.3%）。

由此可见，维生素D缺乏会增加心血管疾病的风险。该非线性孟德尔随机分析支持血清25-羟基维生素D浓度与CVD风险之间存在L形关联，这表明就心血管健康而言，改善维生素D状态对于缺乏的个体而言存在益处。

原始出处：

Ang Zhou,et al.Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk.European Heart Journal.2021.https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehab809/6448753?redirectedFrom=fulltext

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2021-12-21 洁巴子

学习#心血管#

119 0
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2021-12-18 D-House

666

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2021-12-08 zhaojie88

#ART#

76 0
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2021-12-08 花花1368

#疾病风险#

68 0
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2021-12-08 andy2090

#血管疾病#

95 0
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2021-12-08 slcumt

#HEART#

86 0
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2021-12-07 yxppci

VITD

86 0
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2021-12-06 吉星高照4739

维生素D缺乏心血管疾病危险

105 0

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