Foods：吃葡萄可能改变非酒精性脂肪肝、还能大脑基因表达，促进行为与认知功能

来自西新英格兰大学的 John Pezzuto 博士及其团队最近发布的研究表明，葡萄消费的“惊人”影响以及对健康和寿命的“显著”影响。

发表在Foods《食品》杂志上的一项研究表明，在西方国家通常食用的高脂肪饮食中，每天添加不到两杯葡萄的葡萄可以减少脂肪肝并延长寿命。撰写了 600 多项科学研究的 Pezzuto 指出，这些研究为古老的谚语“你就是你所吃的东西”增加了一个全新的维度，他说葡萄的研究显示了基因表达的实际变化。 “这真是了不起。”

本研究通过动物实验表明，葡萄添加剂能减轻脂肪饮食带来的体重增加等不利影响。

Grape powder supplementation of a high-fat diet affects temporal weight loss and increases the lifespan of C57BL/6J mice. (A) At 14-weeks-of-age, mice were divided into two groups (n = 100 per group), and diet was changed from the STD to either the high-fat diet (HFD) or the high-fat diet supplemented with 5% grape powder (HFD5GP) for the remainder of their lifespan. Body weight was recorded every two weeks and recorded as mean ± SD. (B) Kaplan-Meier plot showing the survival of mice provided with the HFD or the HFD5GP. Survival was enhanced with the group provided with the HFD5GP (p = 0.036; log-rank test). The hazard ratio of the HFD group was 1.397 (95% CI, 0.99–1.96), whereas the hazard ratio for the HFD5GP group was 0.715 (95% CI, 0.507–1.009). (C) Correlation plots showing the age at highest body weight versus lifespan for individual mice (upper panels), and the highest body weight attained by individual mice versus lifespan (lower panels).

Pezzuto 博士和他的团队发表在《抗氧化剂》杂志上的另一项研究报告称，食用葡萄会改变大脑中的基因表达，并对因高脂肪饮食而受损的行为和认知产生积极影响。由 Jeffrey Idle 博士领导的团队在《食品与营养》杂志上发表的第三项研究表明，除了基因表达的变化外，葡萄还会改变新陈代谢。

不过，梅斯小编还是要提醒，这些仅仅是动物研究，与人体研究还是有相当大的差别的。科学的研究结果需要人体研究才能更好地说明问题。

原始出处：

Dave A, Park EJ, Kumar A, Parande F, Beyoğlu D, Idle JR, Pezzuto JM.Consumption of Grapes Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity in Female C57BL/6J Mice Provided with a High-Fat Western-Pattern Diet. Foods.2022 Jul 5;11(13):1984.  doi.org/10.3390/foods11131984.

Parande F, Dave A, Park EJ, McAllister C, Pezzuto JM.Effect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes.Antioxidants (Basel). 2022 Feb 18;11(2):414. doi: 10.3390/antiox11020414