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AACR 2016:努力不会白费!多数国家乳腺癌的死亡率逐步下降!

2016-12-15 MedSci MedSci原创

20世纪90年代以来,乳腺癌的检查和管理发生了重大改变。研究人员分析了从1989年到2012年47个国家的乳腺癌的死亡趋势。乳腺癌死亡和人群研究数据来自WHO死亡数据库。使用1987 - 2012年间适用于所有女性,以及适用于50岁以下,50-69岁和≥70岁妇女的世界标准化人群来计算年龄标准化死亡率。1989 - 2012年间评估了死亡率趋势的百分比变化,死亡率以100000为分母。研究者将同一

20世纪90年代以来,乳腺癌的检查和管理发生了重大改变。研究人员分析了从1989年到2012年47个国家的乳腺癌的死亡趋势。

乳腺癌死亡和人群研究数据来自WHO死亡数据库。使用1987 - 2012年间适用于所有女性,以及适用于50岁以下,50-69岁和≥70岁妇女的世界标准化人群来计算年龄标准化死亡率。1989 - 2012年间评估了死亡率趋势的百分比变化,死亡率以100000为分母。研究者将同一区域,经济地位相似,1987-1989年死亡率相同的国家归为一个组。

结果,1987-1989年间,乳腺癌的年死亡率范围从韩国2.6到英格兰和威尔士29.3(中位数18.5)。2010-2012年间,死亡率范围从韩国5.1到丹麦18.4(中位数14.8)。1989到2012年间(23年),47个国家的39个国家的乳腺癌死亡率正逐步下降。死亡率的变化范围从英格兰和威尔士减少45%到韩国增加79%(中位数是-28%)。1987-1989年高死亡率国家的乳腺癌死亡率降低的更为明显。

在同一组国家中,死亡率变化有明显差异,例如,法国降低21%,而西班牙降低37%,拉脱维亚增长5%,而斯洛伐克降低17%。尽管1987-1989年间,澳大利亚死亡率为20.9,新西兰为27.4,但是两个国家的乳腺癌死亡率均降低了38%。值得注意的是,在这一组的国家中,在1990年左右开展大规模乳腺癌筛查的国家死亡率降低幅度和2005年及以后实施的国家一样。

在年龄组方面,除了新西兰和香港,所有国家死亡率下降幅度最大的是低于50岁的女性,在该年龄组,只有三个国家死亡率上升(巴西,哥伦比亚和韩国)。年轻女性的死亡率变化范围从斯洛文尼亚降低59%到韩国增长32%(中位数-45%)。无论是50岁之前很少接受乳腺癌筛查的国家(如挪威,英格兰和威尔士)还是20世纪80年代后期普及筛查的国家(如美国,瑞典),年轻女性的死亡率变化没有什么不同。50-69年龄组,死亡率变化范围从英格兰和威尔士减少49%到韩国增长111%(中位数是-27%)。≥70岁年龄组,死亡率变化范围从荷兰减少33%到韩国增长151%(中位数是-11%)。

总而言之,世界范围内和各年龄组中均可发现乳腺癌死亡率的巨大变化。多数欧洲、北美、澳洲国家,以及少数拉丁美洲和亚洲国家,乳腺癌的死亡率均有下降趋势。对于亚洲高收入国家乳腺癌死亡率的上升较难解释,因为这些国家的患者很容易获得有效的治疗。乳腺癌筛查似乎并不会明显影响乳腺癌的死亡率趋势。

原始出处:

[1] Catharine Paddock. Breast cancer deaths have dropped in many countries. MNT, 12 December 2016.

[2] Cécile Pizot et al., Overview of breast cancer mortality trends in the world, presented at the American Association for Cancer Research 2016 San Antonio Breast Cancer Symposium, 9 December 2016.


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    2016-12-16 Luyuxie_14
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    2016-12-16 sunlong28

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authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Wed Dec 14 10:13:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162686, encodeId=8aa21626863e, content=中国不知道原文里面有没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Wed Dec 14 09:25:13 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162681, encodeId=6ab8162681a7, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2jCrVzt3we3lONuTwkB6ial49Fg4A56Z8882WQVOBzvHs3DsgATyZdSWicZrNzY6ELZkPxUibgVnZDickr6ia0wYW3u/0, createdBy=451f15208, createdName=好运连连9452, createdTime=Wed Dec 14 09:05:38 CST 2016, time=2016-12-14, status=1, ipAttribution=)]
    2016-12-16 sunlong28

    ??????

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1551981, encodeId=d5bb15519815f, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Fri Dec 16 15:00:00 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400358, encodeId=7c2c14003588c, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, 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authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Wed Dec 14 10:13:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162686, encodeId=8aa21626863e, content=中国不知道原文里面有没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Wed Dec 14 09:25:13 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162681, encodeId=6ab8162681a7, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2jCrVzt3we3lONuTwkB6ial49Fg4A56Z8882WQVOBzvHs3DsgATyZdSWicZrNzY6ELZkPxUibgVnZDickr6ia0wYW3u/0, createdBy=451f15208, createdName=好运连连9452, createdTime=Wed Dec 14 09:05:38 CST 2016, time=2016-12-14, status=1, ipAttribution=)]
    2016-12-16 sunlong28

    ?????

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1551981, encodeId=d5bb15519815f, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Fri Dec 16 15:00:00 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400358, encodeId=7c2c14003588c, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, 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authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Wed Dec 14 10:13:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162686, encodeId=8aa21626863e, content=中国不知道原文里面有没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Wed Dec 14 09:25:13 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162681, encodeId=6ab8162681a7, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2jCrVzt3we3lONuTwkB6ial49Fg4A56Z8882WQVOBzvHs3DsgATyZdSWicZrNzY6ELZkPxUibgVnZDickr6ia0wYW3u/0, createdBy=451f15208, createdName=好运连连9452, createdTime=Wed Dec 14 09:05:38 CST 2016, time=2016-12-14, status=1, ipAttribution=)]
    2016-12-15 小树

    这是件好事呀!

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2jCrVzt3we3lONuTwkB6ial49Fg4A56Z8882WQVOBzvHs3DsgATyZdSWicZrNzY6ELZkPxUibgVnZDickr6ia0wYW3u/0, createdBy=451f15208, createdName=好运连连9452, createdTime=Wed Dec 14 09:05:38 CST 2016, time=2016-12-14, status=1, ipAttribution=)]
    2016-12-15 sunlong28

    赞一个~

    0

  8. 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authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Wed Dec 14 10:13:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162686, encodeId=8aa21626863e, content=中国不知道原文里面有没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Wed Dec 14 09:25:13 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162681, encodeId=6ab8162681a7, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2jCrVzt3we3lONuTwkB6ial49Fg4A56Z8882WQVOBzvHs3DsgATyZdSWicZrNzY6ELZkPxUibgVnZDickr6ia0wYW3u/0, createdBy=451f15208, createdName=好运连连9452, createdTime=Wed Dec 14 09:05:38 CST 2016, time=2016-12-14, status=1, ipAttribution=)]
    2016-12-14 1e184d7bm65(暂无匿称)

    棒棒哒???????????

    0

  9. 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authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Wed Dec 14 10:13:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162686, encodeId=8aa21626863e, content=中国不知道原文里面有没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Wed Dec 14 09:25:13 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162681, encodeId=6ab8162681a7, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2jCrVzt3we3lONuTwkB6ial49Fg4A56Z8882WQVOBzvHs3DsgATyZdSWicZrNzY6ELZkPxUibgVnZDickr6ia0wYW3u/0, createdBy=451f15208, createdName=好运连连9452, createdTime=Wed Dec 14 09:05:38 CST 2016, time=2016-12-14, status=1, ipAttribution=)]
    2016-12-14 xiaotaiyang1

    中国不知道原文里面有没有

    0

  10. 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authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Wed Dec 14 10:13:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162686, encodeId=8aa21626863e, content=中国不知道原文里面有没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Wed Dec 14 09:25:13 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162681, encodeId=6ab8162681a7, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2jCrVzt3we3lONuTwkB6ial49Fg4A56Z8882WQVOBzvHs3DsgATyZdSWicZrNzY6ELZkPxUibgVnZDickr6ia0wYW3u/0, createdBy=451f15208, createdName=好运连连9452, createdTime=Wed Dec 14 09:05:38 CST 2016, time=2016-12-14, status=1, ipAttribution=)]
    2016-12-14 好运连连9452

    受益匪浅

    0

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