J Clin Endocrinol Metab：血尿酸在正常范围高限也会增加糖尿病风险

2016-08-25 Moon 译 MedSci原创

血尿酸（SUA）是体内的老旧细胞，还有食物，尤其是富含嘌呤的食物（如动物内脏、海鲜等）在体内新陈代谢过程中，其核酸氧化分解产物就有嘌呤（这种内源性的嘌呤占总嘌呤的80%）。当血尿酸在正常范围内时，会增加糖尿病风险吗？尤其是对于长得瘦看起来很健康的成年人。研究者进行了长达10年的随访队列研究，评估正常高限SUA与正常低限SUA相比，是否会增加糖尿病风险。研究纳入了469947名参与者，基线40-70

血尿酸（SUA）是体内的老旧细胞、食物（尤其是富含嘌呤的食物[如动物内脏、海鲜等]）在体内新陈代谢过程中的产物，其核酸氧化分解产物就有嘌呤（这种内源性的嘌呤占总嘌呤的80%）。

当血尿酸在正常范围内时，会增加糖尿病风险吗？尤其是对于长得瘦看起来很健康的成年人。研究者进行了长达10年的随访队列研究，评估正常高限SUA与正常低限SUA相比，是否会增加糖尿病风险。

研究纳入了469947名参与者，基线40-70岁，2002年测量SUA情况，排除高尿酸血症（SUA＞6.8毫克/分升）、空腹血糖受损、超重或肥胖、慢性心血管或肾脏疾病患者。最后的队列由30302名参与者组成。

校正年龄、体重指数、社会经济状况、吸烟、基线估计肾小球滤过率和基线血糖等情况后，logistic回归模型分析显示，对于女性，SUA水平位于4-5 mg/dL时，糖尿病发生风险增加61%(95% CI, 1.1-2.3)；SUA位于最高水平(SUA, 5-6 mg/dL)的女性，糖尿病风险OR值为2.7 (1.8-4.0)；当男性SUA值位于6-6.8 mg/dL时，糖尿病风险HR为1.35（0.9-2.1）。

结果表明，对于瘦瘦的健康女性，就算血尿酸水平在正常范围内，与正常低限相比，新发糖尿病风险仍然增加。

原始出处：

Shani M.et al.High Normal Uric Acid Levels Are Associated with an Increased Risk of Diabetes in Lean, Normoglycemic Healthy Women.J Clin Endocrinol Metab. 2016 Aug 17:jc20162107. [Epub ahead of print]

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2016-12-04 guojianrong

#Meta#

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2017-05-07 一闲

#MET#

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2016-09-26 ylzr123

关注值得，学习。赞！好文探究。

94 0
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2016-09-20 1e10c84am36(暂无匿称)

文章很好，非常有益

81 0
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2016-09-12 舒心和人

高尿酸血症是继高血压，高血糖，高血糖之后的又一新高

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2016-09-02 1771ae4158m

学习一下好

128 0
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2016-08-31 李东泽

这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。

138 0
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2016-08-31 jyzxjiangqin

发病率越来越高！

52 0
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2016-08-28 忠诚向上

好好学习一下

48 0
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2016-08-27 12498e67m28暂无昵称

#血尿酸#

97 0