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J Clin Periodontol:牙周手术结合抗菌光动力疗法治疗慢性牙周炎的效果观察:一项临床随机对照试验

2017-05-19 lishiting MedSci原创

这篇研究的目的是为了评估单项辅助治疗-抗菌光动力疗法(aPDT)对罹患严重慢性牙周炎(SCP)的患者实施牙周外科手术(ST)时的疗效。研究采用分口设计,将20名罹患SCP患者分别施以aPDT+ST(测试组,TG)或仅ST治疗(对照组,CG)。aPDT的实施是通过二极管激光器和吩噻嗪光敏剂进行单次偶发。在实施牙周手术治疗后,监控所有患者的术后疗效90天。分别在术前、术后60和150天,通过棋盘式DN

这篇研究的目的是为了评估单项辅助治疗-抗菌光动力疗法(aPDT)对罹患严重慢性牙周炎(SCP)的患者实施牙周外科手术(ST)时的疗效。

研究采用分口设计,将20名罹患SCP患者分别施以aPDT+ST(测试组,TG)或仅ST治疗(对照组,CG)。aPDT的实施是通过二极管激光器和吩噻嗪光敏剂进行单次偶发。在实施牙周手术治疗后,监控所有患者的术后疗效90天。分别在术前、术后60和150天,通过棋盘式DNA-DNA杂交法检测40种龈下微生物水平。评估其临床和微生物参数指标。

结果显示,在深牙周袋(PPD ≥ 5 mm)牙周炎中,与对照组相比较,测试组在牙周手术后90天可以显著减弱PPD的程度 (p<0.05)。另外,测试组可以明显减少红色复合物的牙周病原体(梅毒螺旋体)的存在(p<0.05)。

结论:在手术治疗SCP过程中,对牙根表面实施开放皮瓣清创术辅助以单次偶发的aPDT疗法,优点在于:1. 显著改善牙周炎的临床指标;2. 更加有效的清除红色复合物的牙周病原体。

原始出处


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    2017-11-15 feather89
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createdBy=ad9f79, createdName=般若傻瓜, createdTime=Sat Mar 03 08:11:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726409, encodeId=930e1e2640937, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Nov 15 13:11:00 CST 2017, time=2017-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775310, encodeId=1da31e753108a, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Thu Jan 25 01:11:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296162, encodeId=9f25129616288, content=<a href='/topic/show?id=7591984530b' target=_blank style='color:#2F92EE;'>#随机对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98453, encryptionId=7591984530b, topicName=随机对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330572, encodeId=a52c13305e245, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368619, encodeId=ec4613686194a, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450521, encodeId=3670145052181, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546289, encodeId=dad415462890b, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199998, encodeId=f80d19999834, content=牙周炎的治疗,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri May 19 13:48:16 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2018-01-25 amyloid
  5. [GetPortalCommentsPageByObjectIdResponse(id=1668591, encodeId=6f2616685911e, content=<a href='/topic/show?id=543c5569161' target=_blank style='color:#2F92EE;'>#抗菌光动力疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55691, encryptionId=543c5569161, topicName=抗菌光动力疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f4626357531, createdName=shizhenshan, createdTime=Thu Feb 01 21:11:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987172, encodeId=ec1d198e172a2, content=<a href='/topic/show?id=bac5466546c' target=_blank style='color:#2F92EE;'>#对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46654, encryptionId=bac5466546c, topicName=对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, 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encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Thu Jan 25 01:11:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296162, encodeId=9f25129616288, content=<a href='/topic/show?id=7591984530b' target=_blank style='color:#2F92EE;'>#随机对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98453, encryptionId=7591984530b, topicName=随机对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330572, encodeId=a52c13305e245, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368619, encodeId=ec4613686194a, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), 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createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199998, encodeId=f80d19999834, content=牙周炎的治疗,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri May 19 13:48:16 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
  6. 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encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Thu Jan 25 01:11:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296162, encodeId=9f25129616288, content=<a href='/topic/show?id=7591984530b' target=_blank style='color:#2F92EE;'>#随机对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98453, encryptionId=7591984530b, topicName=随机对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330572, encodeId=a52c13305e245, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368619, encodeId=ec4613686194a, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), 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createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199998, encodeId=f80d19999834, content=牙周炎的治疗,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri May 19 13:48:16 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
  7. 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createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199998, encodeId=f80d19999834, content=牙周炎的治疗,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri May 19 13:48:16 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
  8. 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createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199998, encodeId=f80d19999834, content=牙周炎的治疗,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri May 19 13:48:16 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-21 liuyong2982
  9. 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  10. 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createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sun May 21 01:11:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199998, encodeId=f80d19999834, content=牙周炎的治疗,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri May 19 13:48:16 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-19 1e0f8808m18(暂无匿称)

    牙周炎的治疗,学习了。

    0

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