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Metabolism:内脏肥胖在COVID-19严重程度中的作用

2020-07-15 MedSci原创 MedSci原创

内脏脂肪组织和上腹围增加了COVID-19患者病情严重程度的可能性。因此,量化常规胸部CT中的内脏脂肪组织量和上腹围可能是COVID-19患者进行风险评估的简单工具。

最近,肥胖已被确定为2019年冠状病毒病(COVID-19)患者严重疾病的独立危险因素。脂肪分布的作用,尤其是内脏脂肪,通常与代谢综合征有关,在COVID-19患者的严重疾病目前尚不明确。近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,这项研究旨在调查脂肪分布与COVID-19严重程度之间的关系。

该横断面分析纳入了来自德国柏林一级医疗中心的30例COVID-19患者,平均年龄为65.6±13.1岁。通过聚合酶链反应(PCR)检测鼻部和咽拭子样本来确诊COVID-19。研究人员通过受试者入住重症监护病房(ICU)和/或进行有创机械通气来确定COVID-19的严重临床病程。在常规获得的低剂量胸部计算机断层扫描(CT)上测量第一腰椎层面的脂肪量。

内脏脂肪面积(VFA)增加10平方厘米与入住ICU治疗的可能性升高1.37倍,机械通气的可能性增加1.32倍(根据年龄和性别调整)相关。对于上腹围,每增加1厘米,入住ICU治疗的可能性升高1.13倍,机械通气的可能性增加1.25倍。

该验证研究表明,内脏脂肪组织和上腹围增加了COVID-19患者病情严重程度的可能性。因此,量化常规胸部CT中的内脏脂肪组织量和上腹围可能是COVID-19患者进行风险评估的简单工具。

原始出处:

Antonia Petersen,et al.The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany.Metabolism-Clinical and Experimental.2020.https://www.metabolismjournal.com/article/S0026-0495(20)30181-5/fulltext

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    2020-08-14 一闲
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    2020-09-21 guojianrong
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    2020-07-17 闆锋旦
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    2020-07-16 1240394fm61暂无昵称

    大部分都是和新冠有关

    0

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