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Brit J Surg:年轻人结直肠癌发病率的人口统计学趋势

2020-03-11 xing.T MedSci原创

由此可见,大肠癌不应再被视为老年人的疾病。发病率的变化应用于指导未来的筛查政策、预防策略和研究方案,并增加公众对年轻人需要了解结直肠癌症状的认识。

越来越多的证据表明年轻人中结直肠癌的发病率正在增加,但是目前缺乏更好地了解这些趋势相关的描述性流行病学资料。

近日,外科疾病领域权威杂志British Journal of Surgery上发表了一篇研究文章,研究人员进行了一项基于人群的队列研究,纳入了1974年至2015年期间在英格兰诊断为大肠癌的所有20-49岁的成年人。研究人员使用大肠癌的ICD-9/10代码从国家癌症注册和分析服务数据库中提取数据,并使用Joinpoint回归分析了根据性别、解剖位点、多重贫困指数五分五分位数和地理区域分层的特定年龄段发病率的时间趋势。

该研究总共分析了56134例新诊断的大肠癌患者。发病率持续增长最高的是20-29岁人群,主要是由于远端结肠肿瘤的增加。发病率上升的幅度在男性和女性中,以及在多重剥夺指数各五分位数的受试者中均相似,尽管发病率上升最明显的地区为英格兰南部地区。

由此可见,大肠癌不应再被视为老年人的疾病。发病率的变化应用于指导未来的筛查政策、预防策略和研究方案,并增加公众对年轻人需要了解结直肠癌症状的认识。

原始出处:

A. C. Chambers.Demographic trends in the incidence of young‐onset colorectal cancer: a population‐based study.British Journal of Surgery.2020.https://doi.org/10.1002/bjs.11486

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    2020-03-13 siiner
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