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Biomed Res Int:rhBMP-2膜是否可增强成骨?

2017-12-01 MedSci MedSci原创

本研究旨在评估生长因子胶原膜在骨水平生长过程中对新骨形成的影响。研究选择了六只雄性Beagle犬,手术创造了4×4×4 毫米的下颌骨缺损,然后使用3种类型的屏障膜:(1)钛网,(2)钛增强胶原蛋白,(3)rhBMP-2负载钛增强胶原。手术后8周和16周处死动物,并制备未脱钙的标本,测定屏障膜对成骨组织形态学的影响程度。使用弗里德曼检验对数据进行分析。结果显示,在早期成骨度(手术后8周)方面,rhB

本研究旨在评估生长因子胶原膜在骨水平生长过程中对新骨形成的影响。

研究选择了六只雄性Beagle犬,手术创造了4×4×4 毫米的下颌骨缺损,然后使用3种类型的屏障膜:(1)钛网,(2)钛增强胶原蛋白,(3)rhBMP-2负载钛增强胶原。手术后8周和16周处死动物,并制备未脱钙的标本,测定屏障膜对成骨组织形态学的影响程度。使用弗里德曼检验对数据进行分析。

结果显示,在早期成骨度(手术后8周)方面,rhBMP-2膜组新骨形成的比例明显较高(P>0.05)。但长期疗效(术后16周)三个组间无显著性差异(P>0.05)。基于计量分析,在横骨获得率差异无统计学意义(P>0.05)。

原始出处:


Lee KS, Jeon YS, Shin SW, Lee JY. Effects of rhBMP-2 Loaded Titanium Reinforced Collagen Membranes on Horizontal Bone Augmentation in Dogs. Biomed Res Int. 2017;2017:7141296. doi: 10.1155/2017/7141296. Epub 2017 Oct 17.

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    2018-05-30 sunylz
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    2018-07-22 HNYYM
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    2017-12-03 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1793334, encodeId=08b11e9333471, content=<a href='/topic/show?id=a38d15430ea' target=_blank style='color:#2F92EE;'>#rhBMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15430, encryptionId=a38d15430ea, topicName=rhBMP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Thu Oct 04 16:47:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917809, encodeId=be17191e80935, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed May 30 18:47:00 CST 2018, time=2018-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642644, encodeId=d2b216426449b, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Sat May 05 08:47:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634012, encodeId=fa15163401259, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Sun Jul 22 10:47:00 CST 2018, time=2018-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351627, encodeId=56a8135162e7d, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Dec 03 01:47:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608309, encodeId=38fa160830941, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Dec 03 01:47:00 CST 2017, time=2017-12-03, status=1, ipAttribution=)]
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