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Nature:日本研制新型万能细胞STAP

2014-02-07 佚名 网易

日本理化学研究所发生再生科学综合研究中心(位于神户市)的科研小组用新手法成功制作出具有多种分化功能的万能细胞,该成果发表在30日发行的英国《自然》杂志。 据悉,这一方法比诱导多能干细胞(iPS细胞)和胚胎干细胞(ES细胞)的制作方法简单,使用安全性也较高。此次采用的是小鼠,而若用人类细胞制作成功,该成果则有望应用到再生医疗领域。 把体细胞放进弱酸性溶液加以刺激的制作方法在全球尚属首次。制作出的

日本理化学研究所发生再生科学综合研究中心(位于神户市)的科研小组用新手法成功制作出具有多种分化功能的万能细胞,该成果发表在30日发行的英国《自然》杂志。

这一方法比诱导多能干细胞(iPS细胞)和胚胎干细胞(ES细胞)的制作方法简单,使用安全性也较高。此次采用的是小鼠,而若用人类细胞制作成功,该成果则有望应用到再生医疗领域。

把体细胞放进弱酸性溶液加以刺激的制作方法在全球尚属首次。制作出的细胞被命名为“STAP细胞”,分别取自“刺激触发采集多功能”(Stimulus Triggered Acquisition of Pluripotency)的头一字母。

科研团队骨干、研究领头人小保方晴子称:“除了体内器官组织的再生外,STAP细胞还会有助于因细胞应激反应产生的癌症的抑制等新型医疗技术的开发。”

原文出处:

Haruko Obokata,Teruhiko Wakayama,Yoshiki Sasai,Koji Kojima,Martin P. Vacanti,Hitoshi Niwa,Masayuki Yamato& Charles A. Vacanti. Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature, 29 January 2014;

Haruko Obokata,Yoshiki Sasai,Hitoshi Niwa,Mitsutaka Kadota,Munazah Andrabi,Nozomu Takata,Mikiko Tokoro,Yukari Terashita,Shigenobu Yonemura,Charles A. Vacanti& Teruhiko Wakayama. Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature, 29 January 2014;

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    2014-04-29 liye789132251
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    科技决定强盛

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1879904, encodeId=b0d618e99043e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Apr 29 11:35:00 CST 2014, time=2014-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7248, encodeId=3836e24819, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:41:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7246, encodeId=f9b5e24661, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:40:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7247, encodeId=b6b5e2474b, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:40:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7245, encodeId=c8e8e24552, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:39:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294154, encodeId=8ca912941547f, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Feb 09 02:35:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552068, encodeId=c85c155206820, content=<a href='/topic/show?id=078a16e37ed' target=_blank style='color:#2F92EE;'>#STAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16737, encryptionId=078a16e37ed, topicName=STAP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeba14252567, createdName=guoyibin, createdTime=Sun Feb 09 02:35:00 CST 2014, time=2014-02-09, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1879904, encodeId=b0d618e99043e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Apr 29 11:35:00 CST 2014, time=2014-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7248, encodeId=3836e24819, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:41:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7246, encodeId=f9b5e24661, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:40:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7247, encodeId=b6b5e2474b, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:40:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7245, encodeId=c8e8e24552, content=科技决定强盛, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.231.49.186, createdTime=Sun Feb 09 09:39:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294154, encodeId=8ca912941547f, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sun Feb 09 02:35:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1552068, encodeId=c85c155206820, content=<a href='/topic/show?id=078a16e37ed' target=_blank style='color:#2F92EE;'>#STAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16737, encryptionId=078a16e37ed, topicName=STAP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeba14252567, createdName=guoyibin, createdTime=Sun Feb 09 02:35:00 CST 2014, time=2014-02-09, status=1, ipAttribution=)]
    2014-02-09 guoyibin
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