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Stroke:妊娠期间危险因素对子代脑血管病的预测作用

2021-03-02 MedSci原创 MedSci原创

为了预防脑血管疾病,了解生命早期出现的危险因素尤为重要。

为了预防血管疾病,了解生命早期出现的危险因素尤为重要。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究旨在调查孕妇和子代人体测量学指标和妊娠并发症与子代成年后缺血性、出血性卒中和短暂性脑缺血发作风险之间的关系。

在1966年以人群为基础的前瞻性芬兰北部出生队列中,研究人员随访了11991名受试者,从妊娠早期到52岁。研究人员从受试者妊娠第24周至第28周和分娩时收集妊娠和分娩并发症信息。子代的缺血性和出血性卒中发生情况是通过芬兰国家登记中心进行确定。研究人员使用Cox比例风险模型来评估妊娠和分娩并发症与子代脑血管疾病发病率之间的关系,并根据性别、家庭社会经济地位、孕妇年龄和妊娠期间吸烟等因素进行调整。

在568821人次每年的随访中,453名(3.8%)子代发生了卒中或短暂性脑缺血发作。正常体重孕妇妊娠期间体重增加程度较大和较小与子女缺血性卒中风险增加相关(校正后风险比分别为1.93和1.54)。小于胎龄出生体重和小体重指数与缺血性卒中风险增加相关(aHR为1.95[95%CI为1.21-3.13]和aHR为1.36[95%CI为1.04-1.77])。先兆流产也与卒中风险增加相关(aHR为1.64 [95%CI为1.14-2.37])。孕妇吸烟、高血压或分娩并发症与子代患脑血管疾病的风险增加无关。

由此可见,该研究的结果表明,妊娠期母体和胎儿生长障碍可能使子代在成年后易患脑血管疾病

原始出处:

Milja Kivelä.et al.Pregnancy Risk Factors as Predictors of Offspring Cerebrovascular Disease The Northern Finland Birth Cohort Study 1966.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031618

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    2021-05-02 楚钟
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    2021-03-03 鼠叔叔啦啦

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