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Nutr Metab Cardiovasc Dis:我国>70岁人群的LDL-C水平与心血管疾病风险增加相关

2021-12-14 汪文慧 “心关注”公众号

近期,发表在《Nutr Metab Cardiovasc Dis》上的一篇研究显示:在当代中国社会,LDL-C水平的升高增加了70岁以上人群的心血管疾病风险,这提示应加强对老年人群的血脂管理。

近期,发表在《Nutr Metab Cardiovasc Dis》上的一篇研究显示:在当代中国社会,LDL-C水平的升高增加了70岁以上人群的心血管疾病风险,这提示应加强对老年人群的血脂管理

既往研究表明,升高的LDL-C水平与心血管疾病的相关性随年龄的增长变化较大,其在年轻群体中的相关性比在老年群体更高。因此,为明确中国70岁以上人群LDL-C水平与心血管疾病之间的关系,研究人员采用前瞻性队列研究的方法,纳入2011年未服用他汀类药物且未发生心脏病和卒中的中国健康与养老追踪调查(CHARLS)项目的参与者,并随访至2018年。该研究的主要结果是心血管疾病的发生;使用Cox风险回归模型分析LDL-C对心血管疾病的影响。

研究最终共纳入9631例参与者,15.2%(N=1463)的受试者年龄超过70岁。在7年随访期间,1437例参与者首次出现心血管疾病发作。在所有年龄组中,LDL-C每升高10 mg/mL,心血管疾病的风险随之增加。此外,70岁以上人群中LDL-C水平与CVD风险呈U型曲线关系,但进一步分析发现在U型曲线的左侧LDL-C水平与CVD无关,这表明低LDL-C水平并不会增加心血管疾病风险。

原始出处:

Su X, Zheng D, Wang M,et al. Low density lipoprotein cholesterol is associated with increased risk of cardiovascular disease in participants over 70 years old: A prospective cohort study. Nutr Metab Cardiovasc Dis. 2021 Oct 21:S0939-4753(21)00507-X. doi: 10.1016/j.numecd.2021.10.009. Epub ahead of print. PMID: 34893412.

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    2022-04-24 guojianrong
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    2022-11-25 quxin068
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    2021-12-16 zhwj
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