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Clinica Chimica Acta:冠心病患者血中血红素氧合酶-1与胆红素的比较

2020-05-12 MedSci原创 MedSci原创

血红素氧合酶-1 (HO-1)将血红素降解为一氧化碳、铁和胆绿素/胆红素。尽管在冠心病(CAD)患者中经常报告血清胆红素水平,但尚未弄清CAD患者的HO-1水平以及HO-1与胆红素水平之间的关系。

血红素氧合酶-1 (HO-1)将血红素降解为一氧化碳、铁和胆绿素/胆红素。尽管在冠心病(CAD)患者中经常报告血清胆红素水平,但尚未弄清CAD患者的HO-1水平以及HO-1与胆红素水平之间的关系。

研究人员测量了262例冠状动脉造影患者的血浆HO-1和血清总胆红素水平。研究发现CAD患者的HO-1水平高于非CAD患者(中位数为0.46比0.35 ng/mL, P < 0.01),而CAD患者的胆红素水平低于非CAD患者(0.69比0.75 mg/dL, P < 0.02)。值得注意的是,在CAD(−)、1血管、2血管和3血管疾病中HO-1水平分别为0.35、0.51、0.45和0.44 ng/mL,在1血管疾病中最高(P < 0.05)。冠心病(−)、1血管疾病、2血管疾病和3血管疾病中的胆红素水平分别为0.75、0.70、0.68和0.66 mg/dL (P = NS)。HO-1与胆红素水平无相关性。在多变量分析中,HO-1水平是冠心病的重要因素,与动脉粥样硬化危险因素和胆红素水平无关。CAD的比值比为2.32 (95%CI = 1.29-4.17),而高HO-1 (>0.35 ng/mL)的比值比为2.32 (95%CI = 1.29-4.17)。

研究结果表明冠心病患者血液中HO-1水平高,胆红素水平低,但HO-1与胆红素水平无相关性。

原始出处:

Yoshimi KishimotoHanako NikiBlood levels of heme oxygenase-1 versus bilirubin in patients with coronary artery disease

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