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AP&T: 慢性乙型肝炎会增加B细胞非霍奇金淋巴瘤和多发性骨髓瘤发生风险

2019-02-16 不详 MedSci原创

目前对于慢性乙型肝炎与淋巴瘤发生之间是否存在关系还没有定论,因此本项研究的目的是确定慢性乙型肝炎和淋巴瘤之间的关联。

背景
目前对于慢性乙型肝炎与淋巴瘤发生之间是否存在关系还没有定论,因此本项研究的目的是确定慢性乙型肝炎和淋巴瘤之间的关联。

方法
研究人员从台湾国家健康保险研究数据库中检索了2004 - 2007年间被诊断患有慢性乙型肝炎或非HBV的患者记录。使用两个队列之间的倾向评分来匹配年龄,性别,合并症和医学随访,并且纵向跟踪他们直到2012年以确定任何新的淋巴瘤发生。

结果
每个队列都纳入203 031名患者,平均随访7-9年。HBV队列中的淋巴瘤发病率显着高于非HBV队列(29.4 vs 15.9 / 10万人年,P  <0.0001)。在调整合并症后,发现HBV感染是与淋巴瘤发展([HR]:2.07,95%[CI]:1.76-2.43,P <0.0001)和非霍奇金淋巴瘤(HR:2.18,95%CI:1.80-2.65,P  <0.0001)相关的独立危险因素; 特别是弥漫性大B细胞淋巴瘤的风险增加(HR:2.69,95%CI:2.05-3.52,P  <0.0001),并且还用于多发性骨髓瘤(HR:1.63,95%CI:1.10-2.42,P  = 0.016)显着相关。即使在第一年内排除淋巴瘤发展后,该关联仍然显着(HR:2.08,95%CI:1.75-2.47,P  <0.0001)。

结论
慢性乙型肝炎与淋巴瘤风险增加有关,尤其是B细胞非霍奇金淋巴瘤,并且多发性骨髓瘤的风险也会显着增加。

原始出处:

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    2019-04-17 jml2009
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    2019-02-17 183****7028

    学习

    0

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    2019-02-16 天地飞扬

    了解一下,谢谢分享!

    0

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骨病在慢性胰腺炎(CP)患者中很常见,而维生素K对骨代谢至关重要,本项研究的目的是评估CP患者骨质疏松症和骨质减少的患病率,并研究骨病和CP特征与营养参数之间的关系,尤其是维生素D和K水平对于骨病的影响。

Plos Med:血清尿酸盐水平对慢性肾病风险没有影响

有研究表明血清尿酸(SU)水平与慢性肾病(CKD)风险之间存在强烈的正相关; 然而,这种关系是否是因果关系仍然不确定。因此,本研究旨在评估SU水平对CKD风险和估计肾小球滤过率(eGFR)是否存在因果效应。

BMC Gastroenterology: 间充质干细胞通过抑制小鼠中Toll样受体-4的活性来改善小鼠慢性结肠炎症

目前已知多种肠外表现(EIM)包括肝胆并发症,都与与炎性肠病(IBD)有关。也有报道显示间充质干细胞(MSC)移植在IBD的治疗中发挥有潜在的疗效。因此,本研究旨在探讨间充质干细胞(MSC)在使用硫酸葡聚糖钠(DSS)诱导的小鼠慢性结肠炎模型的改善作用。

J Gastroenterology:lusutrombopag可在慢性肝病射频消融术中增加血小板的数量

血小板减少症是慢性肝病(CLD)患者进行侵入性操作的障碍。因此,本项研究的目的是评估lusutrombopag适当的剂量,并评估lusutrombopag用于治疗CLD患者原发性肝癌的经皮肝射频消融术(RFA)前血小板减少症的疗效和安全性。

J Gastroenterology:结晶乳果糖制剂(SK-1202)在日本慢性便秘患者中的疗效和安全性分析

乳果糖制剂在治疗慢性便秘的临床证据目前还比较匮乏。因此,研究人员对患有慢性便秘的日本患者进行了一项随机,双盲,安慰剂对照的剂量研究,以估计乳果糖的最佳临床剂量。

Clinical Translational Gastro: 不同基因型会导致慢性胰腺炎的不同临床结局

罕见的致病基因突变SPINK1,PRSS1,CTRC和CFTR与发展中国家中的慢性胰腺炎(CP)的发生风险密切相关。然而,它们对疾病发病年龄和临床结果的潜在影响,以及它们与环境危险因素的潜在相互作用仍不清楚。因此,本文就此展开了相关研究。

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