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Stroke:烟雾病儿童间接旁路术后长期疗效

2019-09-25 xing.T MedSci原创

由此可见,间接搭桥手术可以为烟雾病患儿的整体临床预后和长期卒中预防提供令人满意的长期改善。

在烟雾病患儿中,很少有关于外科手术预防卒中功效的研究报道。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员在一个单中心评估了大量接受间接旁路手术的烟雾病患儿长期效果。

从1988年8月至2012年12月,有772名患儿接受了间接旁路手术。这项研究纳入了629例随访时间超过5年的患儿,其中不包括Moyamoya综合征患者。平均临床随访时间为12年(范围为5-29年)。根据Karnofsky绩效量表或Lansky Play绩效量表进行横断面分析,以评估总体临床结局和与不良结局相关的因素。为了分析手术的纵向效果,研究人员采用人年法计算间接旁路手术后手术半球出现症状性梗塞或出血的年度风险,并使用Kaplan-Meier方法评估无事件生存率。

95%的患者总体临床结局良好,手术半球的症状性梗塞和出血的年度风险分别为0.08%和0.04%。此外,有症状的梗塞和出血的10年无事件生存率分别为99.2%和99.8%。

由此可见,间接搭桥手术可以为烟雾病患儿的整体临床预后和长期卒中预防提供令人满意的长期改善。 

原始出处:

Eun Jin Ha.et al.Long-Term Outcomes of Indirect Bypass for 629 Children With Moyamoya Disease Longitudinal and Cross-Sectional Analysis.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.025609

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    2019-09-25 内科新手

    谢谢梅斯提供这么好的信息,学到很多

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