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Diabetic Med:未控制的糖尿病患者拒绝胰岛素治疗和胰岛素启动延迟

2018-01-04 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于未控制的糖尿病患者拒绝胰岛素治疗和胰岛素启动的延迟的研究。 研究人员设计和验证一种自然语言处理算法,以从医师的病史文本中确定拒绝胰岛素治疗,并确定拒绝胰岛素治疗的比率及其对胰岛素启动的影响。研究人员使用公共可用的自然语言处理平台Canary设计了该算法。从大型学术医疗中心的电子病历系统随机选择的1501个初级保健医师的笔记评估算法

近日,国际杂志 《Diabetic Med》上在线发表一项关于未控制的糖尿病患者拒绝胰岛素治疗和胰岛素启动的延迟的研究。

研究人员设计和验证一种自然语言处理算法,以从医师的病史文本中确定拒绝胰岛素治疗,并确定拒绝胰岛素治疗的比率及其对胰岛素启动的影响。研究人员使用公共可用的自然语言处理平台Canary设计了该算法。从大型学术医疗中心的电子病历系统随机选择的1501个初级保健医师的笔记评估算法准确性。然后利用经验证的语言模型,研究了2000年至2014年拒绝胰岛素治疗的比率。

该算法确定了拒绝胰岛素治疗敏感性为100%(95CI 82.4-100),阳性预测值为95%(95CI 74.4-99.9)的,特异性为99.9%(95CI 99.6 -100.0)。研究人员确定了3295例无胰岛素的成年2糖尿病患者,推荐使用胰岛素治疗; 其中984人(29.9%)一开始拒绝胰岛素。HbA 1C 75毫摩尔/摩尔(9.0%)与HbA 1c 53-63毫摩尔/摩尔(7.0-7.9%)和64-74 mmol / mol8.0-8.9; P <0.0001)的患者更可能[766/223934.2%)]出现胰岛素治疗降低。这些在最初拒绝胰岛素到最终开始胰岛素治疗的人群 [374/98438.0%)],胰岛素启动的平均时间为790天。

拒绝胰岛素治疗是常见的,可能导致高血糖发展和血糖控制的延迟。因此需要进一步的调查来确定这一重要临床现象的原因,危险因素和长期预后。

原始出处:

N. Hosomura, S. Malmasi, D. Timerman,et al. Decline of insulin therapy and delays in insulin initiation in people with uncontrolled diabetes mellitus

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    2018-06-04 baoya
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1760454, encodeId=01461e6045488, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Jan 26 00:00:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749902, encodeId=3fba1e49902a6, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Jun 04 21:00:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638323, encodeId=897d1638323dc, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jul 25 15:00:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970560, encodeId=381419e056048, content=<a href='/topic/show?id=fa5d5919df' target=_blank style='color:#2F92EE;'>#Diabetic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5919, encryptionId=fa5d5919df, topicName=Diabetic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Tue May 08 00:00:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474394, encodeId=a22c14e439403, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Jan 06 05:00:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514645, encodeId=370a151464585, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Sat Jan 06 05:00:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608407, encodeId=9632160840e0f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Jan 06 05:00:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275433, encodeId=d1d32e543388, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jan 04 16:13:47 CST 2018, time=2018-01-04, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1760454, encodeId=01461e6045488, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Jan 26 00:00:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749902, encodeId=3fba1e49902a6, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Jun 04 21:00:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638323, encodeId=897d1638323dc, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jul 25 15:00:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970560, encodeId=381419e056048, content=<a href='/topic/show?id=fa5d5919df' target=_blank style='color:#2F92EE;'>#Diabetic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5919, encryptionId=fa5d5919df, topicName=Diabetic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Tue May 08 00:00:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474394, encodeId=a22c14e439403, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Jan 06 05:00:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514645, encodeId=370a151464585, content=<a href='/topic/show?id=c8d68389847' target=_blank style='color:#2F92EE;'>#胰岛素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83898, encryptionId=c8d68389847, topicName=胰岛素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e51610667367, createdName=zjshifan_98647309, createdTime=Sat Jan 06 05:00:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608407, encodeId=9632160840e0f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Jan 06 05:00:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275433, encodeId=d1d32e543388, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jan 04 16:13:47 CST 2018, time=2018-01-04, status=1, ipAttribution=)]
    2018-01-04 139****5926

    好好文章学习了

    0

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