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AM J MED:外源性睾酮治疗会增加心血管风险吗?

2016-10-20 MedSci MedSci原创

外源性睾酮治疗与其他治疗或安慰剂相比,是否会增加男性的严重心血管事件风险? 本项系统回顾和荟萃分析,纳入了相关随机对照试验(RCT)和观察性研究,参与者为18岁或以上男性,接受外源性睾酮治疗3天或以上。 主要结果是全因死亡、心肌梗死和卒中。次要终点是其他临床结果,如心脏衰竭、心律失常和心脏手术。 共纳入39项随机对照试验和10项观察性研究。使用30项随机对照试验的数据合并后进行荟

外源性睾酮治疗与其他治疗或安慰剂相比,是否会增加男性的严重心血管事件风险?

本项系统回顾和荟萃分析,纳入了相关随机对照试验(RCT)和观察性研究,参与者为18岁或以上男性,接受外源性睾酮治疗3天或以上。

主要结果是全因死亡、心肌梗死卒中。次要终点是其他临床结果,如心脏衰竭、心律失常和心脏手术。

共纳入39项随机对照试验和10项观察性研究。使用30项随机对照试验的数据合并后进行荟萃分析。

结果显示,与安慰剂组相比,外源性睾酮治疗不会增加心肌梗死风险(OR 0.87, 95% CI 0.39-1.93, 16 RCTs),不会增加卒中风险(OR 2.17, CI 0.63-7.54, 9 RCTs),不会增加全因死亡风险(OR 0.88, CI 0.55-1.41, 20 RCTs)。

观察性研究之间具有显著的临床和方法学上的异质性。由于偏倚高风险、不精确性和不一致性,这些证据被评为低质量证据。

随机对照试验进行的荟萃分析,没有发现外源性睾酮治疗和心肌梗死、卒中或死亡风险之间的联系。至于观察性研究,证据质量太低,外源性睾酮治疗的心血管效应没有明确结论。

原始出处:

G. Caleb Alexander,et al.Cardiovascular risks of exogenous testosterone use among men: A systematic review and meta-analysis.AM J MED.Articles in Press

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    2017-02-05 zhangph
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    2016-10-23 1def6e10m76(暂无匿称)

    心血管风险高

    0

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