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Clin Chem:成人乳制品摄入量与身体组成和心脏代谢特征的关系如何?

2019-08-03 gladiator MedSci原创

在流行病学研究中,关于乳制品摄入量与身体组成和心脏代谢特征之间的关系一直未得到明确的观察研究,而且因果关系也不明确。<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-fareast-font

流行病学研究中,关于乳制品摄入量与身体组成和心脏代谢特征之间的关系一直未得到明确的观察研究,而且因果关系也不明确。

研究人员使用位于乳糖酶基因上游的已建立的遗传变异体(LCT-13910 C/Trs4988235)进行孟德尔随机分析,该变异是与乳制品摄入量相关的工具变量(IV)。     研究过程中18个研究的182041名参与者通过IV估计量对乳制品摄入量对身体成分和心脏代谢特征(脂质,血糖性状和炎症因子)的因果影响进行了量化。

研究发现,每天一份的高乳品摄入量与较高的非脂质SE= 0.117 kg0.035; P = 0.001],血红蛋白A1c较高[0.009%(0.002; P <0.001]LDL [-0.014 mmol / L0.006; P = 0.013],总胆固醇TC[ -  0.012 mmol / L0.005; P = 0.023],非HDL [-0.012mmol / L0.005; P = 0.028]相关。 LCT-13910 C / T CT + TT基因型与比每天乳制品高0.214SE = 0.047; P <0.001),比腰围高0.284cmSE = 0.118; P = 0.017),比非脂质高0.112 kg SE = 0.027; P = 3.8×10-5),以及LDL降低0.032mmol / LSE = 0.009; P = 0.001),TC降低0.032mmol / LSE = 0.010; P = 0.001)相关。在多次测试校正后,遗传上较高的乳品摄入量与非脂质增加有关[每餐每天0.523千克(​​0.170);(0.05 / 18),P = 0.002]。然而,研究人员发现遗传上较高的乳制品摄入量与脂质和血糖特征无关。

本研究结果支持较高的乳制品摄入量对成年人非脂质体重增加的潜在因果影响。研究结果表明,观察到的乳制品摄入量与血脂和血糖特征之间相关性可能并不准确。

原始出处:

Mendelian Randomization of Dairy Consumption Working Group,Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies

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    2019-11-13 lmm397
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