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Neurology:丁苯那嗪治疗不会增加亨廷顿患者抑郁或自杀风险

2018-06-22 zhangfan MedSci原创

研究认为,亨廷顿病患者服用丁苯那嗪不会增加抑郁或自杀风险,对于存在抑郁症病史的人群,丁苯那嗪治疗也是十分安全的

近日研究人员考察了亨廷顿病(HD)治疗药物丁苯那嗪(TBZ)与HD患者抑郁或自杀风险之间的关系。

Enroll-HD研究为回顾性纵向队列研究,采用多因素逻辑回归分析考察了TBZ使用与HD患者抑郁和/或自杀风险之间的关系。对于抑郁和自杀这两个因变量,分别对所有参与者、只有抑郁史及无抑郁症史人群进行考察,调整CAG重复序列、总运动评分、总功能能力、符号数字模态测试分数、性别、疾病持续时间、抑郁症史、抗精神病药物和抗抑郁药物的使用的结果的影响。

相对于未服用TBZ人群(n = 3548),TBZ使用者(n = 543)抑郁风险未见显著变化(OR=0.78),且TBZ使用人群的自杀风险降低(OR = 0.61);对于抑郁症史人群,TBZ治疗导致患者抑郁发作(OR = 0.71)或自杀(OR = 0.57)风险降低;对于无抑郁史人群,TBZ治疗对患者抑郁发作(OR = 1.59)或自杀(OR = 1.43)无显著影响。

研究认为,亨廷顿病患者服用丁苯那嗪不会增加抑郁或自杀风险,对于存在抑郁症病史的人群,丁苯那嗪治疗也是十分安全的。

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    2018-09-15 yinhl1978
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    2018-06-22 183****7028

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