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J Hypertens:中心血压与UAE相关性不优于周围血压

2012-11-16 高晓方译 医学论坛网

  西班牙学者的一项研究表明,尽管中心血压(cBP)与尿蛋白排泄率(UAE)相关,但其相关性不优于诊室血压。论文于2012年11月7日在线发表于《高血压杂志》(J Hypertens)。   此项研究共纳入324例伴有胰岛素抵抗的高血压患者;受试者年龄为(65±10)岁,男性为61%,糖尿病患者为77%,非糖尿病代谢综合征患者为23%。测定诊室周围血压(pBP),并通过三次晨尿样本计算

  西班牙学者的一项研究表明,尽管中心血压(cBP)与尿蛋白排泄率(UAE)相关,但其相关性不优于诊室血压。论文于2012年11月7日在线发表于《高血压杂志》(J Hypertens)。

  此项研究共纳入324例伴有胰岛素抵抗的高血压患者;受试者年龄为(65±10)岁,男性为61%,糖尿病患者为77%,非糖尿病代谢综合征患者为23%。测定诊室周围血压(pBP),并通过三次晨尿样本计算UAE平均值。对伴或不伴微量蛋白尿患者的差异,以及UAE与pBP和cBP的相关性加以分析。利用非劣性检测对上述相关性的强度进行对比。

  结果显示,25%的患者检测出微量蛋白尿。对年龄和性别进行校正后,微量蛋白尿组的中心和周围收缩压以及脉压均高于非微量蛋白尿组(P<0.05)。对于中心收缩压、周围收缩压、中心脉压和周围脉压而言,血压和UAE之间的部分偏相关系数分别为0.175、0.143、0.124和0.092。就与UAE或微量蛋白尿的相关性而言,cBP和pBP彼此间均不占优势。伴或不伴微量蛋白尿患者在cBP和pBP偏相关系数大小或均值方面均无差异。

 

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    2013-10-30 feather89
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