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JCEM:伴有产前并发症孕妇Kisspeptin水平的变化规律

2021-08-26 MedSci原创 MedSci原创

该研究描绘了循环kisspeptin水平不同孕期的变化,并评估了kisspeptin作为产前并发症生物标志物的潜力。

妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志物,但探究伴有产前并发症的女性妊娠早期、中期和晚期循环Kisspeptin水平的数据十分有限。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估伴有产前并发症的女性Kisspeptin水平是否发生改变。

伴有产前并发症的女性(n=105)和那些无并发症孕妇(n=265)在每个孕期(2014年3月至2017年3月)至少接受一次连续超声扫描和采血。该研究的参与者为伴有产前并发症的女性:HDP(n=32)、FGR(n=17)、GDM(n=35)和PTB(n=11)以及10名患有多种并发症的女性,共收集了373份血液样本,另外265名对照者,共采集了930份样本。该研究的主要结局为循环kisspeptin水平的差异程度。

HDP患者妊娠晚期kisspeptin水平高于对照者,但在FGR患者中较低。根据胎龄、孕妇年龄、种族、BMI、吸烟和产次调整后,血浆kisspeptin每增加1nmol/L对应HDP的几率增加了30%(95%CI为16-47%;p<0.0001),FGR降低了28%(95%CI为4-46%;p=0.025)。受PTB影响的孕妇Kisspeptin中位数较高(p=0.014),受GDM影响的孕妇Kisspeptin水平较低(p=0.020),但在多变量分析中并不显著。

由此可见,该研究描绘了循环kisspeptin水平不同孕期的变化,并评估了kisspeptin作为产前并发症生物标志物的潜力。

原始出处:

Ali Abbara.et al.Changes in circulating kisspeptin levels during each trimester in women with antenatal complications.JCEM.2021.https://doi.org/10.1210/clinem/dgab617

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    2021-11-26 feather89
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    2022-03-04 achengzhao
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    2021-09-26 仁者大医
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createdAvatar=https://img.medsci.cn/20210814/61deb584a399410ca9b720adee4e6850/71825fee35134aee90c3ed9dfe89b69f.jpg, createdBy=3cff5430616, createdName=云舒, createdTime=Wed Sep 01 22:10:49 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758356, encodeId=d12f1e5835611, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun May 15 18:50:38 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502604, encodeId=426615026049b, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sat Aug 28 10:50:38 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011862, encodeId=a48a101186233, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/36b917162271482eaf32bc254e6a8bf8/fe860d9f5ee84e4e99f4d8eec4d040c6.jpg, createdBy=c5985256032, createdName=夭夭妖精, createdTime=Thu Aug 26 23:13:05 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011858, encodeId=32941011858ae, content=妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Thu Aug 26 22:51:32 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011830, encodeId=09731011830ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210826/49e8a7cf422140a09ac98326ab420002/caa992ccceda43e5a59eb9466dcd8790.jpg, createdBy=04465483950, createdName=ms9000001764309203, createdTime=Thu Aug 26 21:38:16 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011823, encodeId=14ff10118234a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Aug 26 21:18:25 CST 2021, time=2021-08-26, status=1, ipAttribution=)]
    2021-09-01 云舒

    吸引

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1729096, encodeId=aee41e29096a3, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Nov 26 09:50:38 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063490, encodeId=b4772063490c2, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Mar 04 22:50:38 CST 2022, time=2022-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778108, encodeId=7a881e78108b9, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Sep 26 03:50:38 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1013571, encodeId=a5ab10135e1a3, content=吸引, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sat Aug 28 10:50:38 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011862, encodeId=a48a101186233, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/36b917162271482eaf32bc254e6a8bf8/fe860d9f5ee84e4e99f4d8eec4d040c6.jpg, createdBy=c5985256032, createdName=夭夭妖精, createdTime=Thu Aug 26 23:13:05 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011858, encodeId=32941011858ae, content=妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Thu Aug 26 22:51:32 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011830, encodeId=09731011830ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210826/49e8a7cf422140a09ac98326ab420002/caa992ccceda43e5a59eb9466dcd8790.jpg, createdBy=04465483950, createdName=ms9000001764309203, createdTime=Thu Aug 26 21:38:16 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011823, encodeId=14ff10118234a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Aug 26 21:18:25 CST 2021, time=2021-08-26, status=1, ipAttribution=)]
    2022-05-15 丁鹏鹏
  6. [GetPortalCommentsPageByObjectIdResponse(id=1729096, encodeId=aee41e29096a3, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Nov 26 09:50:38 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063490, encodeId=b4772063490c2, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, 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channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sat Aug 28 10:50:38 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011862, encodeId=a48a101186233, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/36b917162271482eaf32bc254e6a8bf8/fe860d9f5ee84e4e99f4d8eec4d040c6.jpg, createdBy=c5985256032, createdName=夭夭妖精, createdTime=Thu Aug 26 23:13:05 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011858, encodeId=32941011858ae, content=妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Thu Aug 26 22:51:32 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011830, encodeId=09731011830ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210826/49e8a7cf422140a09ac98326ab420002/caa992ccceda43e5a59eb9466dcd8790.jpg, createdBy=04465483950, createdName=ms9000001764309203, createdTime=Thu Aug 26 21:38:16 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011823, encodeId=14ff10118234a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Aug 26 21:18:25 CST 2021, time=2021-08-26, status=1, ipAttribution=)]
    2021-08-28 qilu_qi
  7. 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channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sat Aug 28 10:50:38 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011862, encodeId=a48a101186233, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/36b917162271482eaf32bc254e6a8bf8/fe860d9f5ee84e4e99f4d8eec4d040c6.jpg, createdBy=c5985256032, createdName=夭夭妖精, createdTime=Thu Aug 26 23:13:05 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011858, encodeId=32941011858ae, content=妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Thu Aug 26 22:51:32 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011830, encodeId=09731011830ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210826/49e8a7cf422140a09ac98326ab420002/caa992ccceda43e5a59eb9466dcd8790.jpg, createdBy=04465483950, createdName=ms9000001764309203, createdTime=Thu Aug 26 21:38:16 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011823, encodeId=14ff10118234a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Aug 26 21:18:25 CST 2021, time=2021-08-26, status=1, ipAttribution=)]
    2021-08-26 夭夭妖精

    受益匪浅

    0

  8. 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channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sat Aug 28 10:50:38 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011862, encodeId=a48a101186233, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/36b917162271482eaf32bc254e6a8bf8/fe860d9f5ee84e4e99f4d8eec4d040c6.jpg, createdBy=c5985256032, createdName=夭夭妖精, createdTime=Thu Aug 26 23:13:05 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011858, encodeId=32941011858ae, content=妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Thu Aug 26 22:51:32 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011830, encodeId=09731011830ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210826/49e8a7cf422140a09ac98326ab420002/caa992ccceda43e5a59eb9466dcd8790.jpg, createdBy=04465483950, createdName=ms9000001764309203, createdTime=Thu Aug 26 21:38:16 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011823, encodeId=14ff10118234a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Aug 26 21:18:25 CST 2021, time=2021-08-26, status=1, ipAttribution=)]
    2021-08-26 1453df99m58暂无昵称

    妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1729096, encodeId=aee41e29096a3, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Nov 26 09:50:38 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063490, encodeId=b4772063490c2, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Mar 04 22:50:38 CST 2022, time=2022-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778108, encodeId=7a881e78108b9, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Sep 26 03:50:38 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1013571, encodeId=a5ab10135e1a3, content=吸引, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210814/61deb584a399410ca9b720adee4e6850/71825fee35134aee90c3ed9dfe89b69f.jpg, createdBy=3cff5430616, createdName=云舒, createdTime=Wed Sep 01 22:10:49 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758356, encodeId=d12f1e5835611, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun May 15 18:50:38 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502604, encodeId=426615026049b, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sat Aug 28 10:50:38 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011862, encodeId=a48a101186233, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/36b917162271482eaf32bc254e6a8bf8/fe860d9f5ee84e4e99f4d8eec4d040c6.jpg, createdBy=c5985256032, createdName=夭夭妖精, createdTime=Thu Aug 26 23:13:05 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011858, encodeId=32941011858ae, content=妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Thu Aug 26 22:51:32 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011830, encodeId=09731011830ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210826/49e8a7cf422140a09ac98326ab420002/caa992ccceda43e5a59eb9466dcd8790.jpg, createdBy=04465483950, createdName=ms9000001764309203, createdTime=Thu Aug 26 21:38:16 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011823, encodeId=14ff10118234a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Aug 26 21:18:25 CST 2021, time=2021-08-26, status=1, ipAttribution=)]
    2021-08-26 ms9000001764309203

    非常棒

    0

  10. 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createdAvatar=https://img.medsci.cn/20210814/61deb584a399410ca9b720adee4e6850/71825fee35134aee90c3ed9dfe89b69f.jpg, createdBy=3cff5430616, createdName=云舒, createdTime=Wed Sep 01 22:10:49 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758356, encodeId=d12f1e5835611, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun May 15 18:50:38 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502604, encodeId=426615026049b, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sat Aug 28 10:50:38 CST 2021, time=2021-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011862, encodeId=a48a101186233, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/36b917162271482eaf32bc254e6a8bf8/fe860d9f5ee84e4e99f4d8eec4d040c6.jpg, createdBy=c5985256032, createdName=夭夭妖精, createdTime=Thu Aug 26 23:13:05 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011858, encodeId=32941011858ae, content=妊娠期高血压疾病(HDP)、胎儿生长受限(FGR)、妊娠糖尿病(GDM)和早产(PTB)等产前并发症与胎盘功能障碍有关。Kisspeptin已成为胎盘功能的标志。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Thu Aug 26 22:51:32 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011830, encodeId=09731011830ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210826/49e8a7cf422140a09ac98326ab420002/caa992ccceda43e5a59eb9466dcd8790.jpg, createdBy=04465483950, createdName=ms9000001764309203, createdTime=Thu Aug 26 21:38:16 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011823, encodeId=14ff10118234a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/accee45229794aee9359e274d0a2c508/c7705fe7d0b64e89bfeafe973c005d6e.jpg, createdBy=cdbf2000330, createdName=04754, createdTime=Thu Aug 26 21:18:25 CST 2021, time=2021-08-26, status=1, ipAttribution=)]
    2021-08-26 04754

    学习了

    0

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2012年10月19日 讯 /生物谷BIOON/ --在一项最新的研究中,来自法国国家健康与医学研究院(INSERM)的研究人员在小鼠体内发现了影响生殖的高泌乳素血症(hyperprolactinaemia)变化的内在机制。相关研究结果于近期刊登在Journal of Clinical Investigation期刊上。 高泌乳素血症是停止排卵的一个主要原因,而且导致月经失调和不孕。然而,人们对

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