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COVID-19候选疫苗(PittCoVacc,匹兹堡冠状病毒疫苗):动物实验显成效

2020-04-03 Allan MedSci原创

美国匹兹堡大学医学院的一项研究显示,一款针对新冠病毒的候选疫苗在小鼠中进行了测试,通过指尖大小的贴片递送的疫苗会产生针对新冠病毒的特异性抗体,其数量足以中和病毒。

美国匹兹堡大学医学院的一项研究显示,一款针对新冠病毒的候选疫苗在小鼠中进行了测试,通过指尖大小的贴片递送的疫苗会产生针对新冠病毒的特异性抗体,其数量足以中和病毒。该论文近日发表在《柳叶刀》杂志旗下的《EBioMedicine》之上。研究人员之所以能够迅速采取行动,是因为他们已经在更早的冠状病毒中奠定了基础。

与刚刚进入临床试验的实验性mRNA候选疫苗相比,本文所述的疫苗PittCoVacc(匹兹堡冠状病毒疫苗的简称)使用了一种更为成熟的方法,即使用实验室制造的病毒蛋白片段来增强机体的免疫力,与当前的流感预防疫苗的原理相同。

研究人员还使用微阵列的新颖方法来递送药物,以提高药效。这种阵列是一种指尖大小的、拥有400个小针的贴片,可将刺突蛋白碎片传递到皮肤,这样的贴片可像创可贴一样使用。

 

原始出处:

https://www.firstwordpharma.com/node/1712815

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