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JNCI:HIV感染或增加美国男性肛门癌发病率

2012-10-08 网络 网络

  在感染HIV的人群中肛门癌的发病率增高。因此,HIV的流行情况可能影响美国肛门癌的发病情况。Meredith S. Shiels等旨在估计HIV感染情况对美国1980年至2005年肛门癌发病率的作用。他们的研究结果发表在JNCI 10月最新的在线期刊上。   肛门癌患者的资料(无论是否患者AIDS)来自HIV/AIDS癌症配对研究。未发展至AIDS的HIV感染的肛门癌患者定义为肛门癌的确诊在

  在感染HIV的人群中肛门癌的发病率增高。因此,HIV的流行情况可能影响美国肛门癌的发病情况。Meredith S. Shiels等旨在估计HIV感染情况对美国1980年至2005年肛门癌发病率的作用。他们的研究结果发表在JNCI 10月最新的在线期刊上。

  肛门癌患者的资料(无论是否患者AIDS)来自HIV/AIDS癌症配对研究。未发展至AIDS的HIV感染的肛门癌患者定义为肛门癌的确诊在AIDS诊断之前。同时研究者也计算了HIV感染者罹患肛门癌者在总体人群中所占的比例。通过结合点对数线性模型计算总体人群中肛门癌发病率的变化趋势和不包括合并HIV感染肛门癌患者后发病率的年平均变化百分比和95%可信区间。所有发病率的计算都以2000年美国人群的年龄、性别和种族作为标准。

  在1980至2005年期间,在20533名肛门癌患者中,8.1%为HIV感染患者。在2001年至2005年期间,感染HIV的肛门癌患者所占比例最高,女性为1.2%、男性为28.4%。在1980年至2005年期间,在1980年至2005年期间,HIV感染并没有影响女性肛门癌的发病率,其年发病率仅增加了3.3%,而在没有HIV感染的人群中肛门癌的发病率也增加了3.3%。但是HIV感染却对男性肛门癌的发病率带来了显着的影响,发病率增加了3.4%,在没有HIV感染的人群中,肛门癌的发病率仅增加了1.7%。

  从研究结果中可以看出,在1980年至2005年期间,美国男性肛门癌发病率的增加主要受到HIV感染流行的影响,而女性则不受影响。

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    2012-11-20 lifestar
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    2013-06-09 hxj0127
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    2012-11-12 lanyan20020086

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