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Clin Chem:HDL胆固醇浓度和自身免疫性疾病风险关系如何?

2019-07-21 不详 MedSci原创

在数量级上,高密度脂蛋白是大多数物种中最重要的脂蛋白,研究表明,高密度脂蛋白在正常免疫功能中发挥重要作用。我们测试了高密度脂蛋白胆固醇浓度与自身免疫性疾病风险相关的假设。<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-ser

在数量级上,高密度脂蛋白是大多数物种中最重要的脂蛋白,研究表明,高密度脂蛋白在正常免疫功能中发挥重要作用。我们测试了高密度脂蛋白胆固醇浓度与自身免疫性疾病风险相关的假设。

通过对普通人群的两项研究:即哥本哈根普通人群研究和哥本哈根城市心脏研究——本研究纳入了107954名和9387名参与者,基线测量他们的HDL胆固醇的水平。从2003年至2015年或1991年至1994年至2017年,丹麦国家患者登记中心(national Patient Registry)对这些患者进行了随访,在这两项研究中,4078人和1101人出现了自身免疫性疾病。

研究显示,在哥本哈根普通人群的研究中,与HDL胆固醇≥2.0mmol/ L77 mg / dL)的个体相比,高密度脂蛋白胆固醇为为1.5-1.99 mmol / L58-77 mg / dL)的个体, 高密度脂蛋白胆固醇为1.0-1.49 mmol / L39-58 mg / dL)的个体,以及高密度脂蛋白胆固醇<1.0 mmol / L39 mg / dL)的个体的任何自身免疫性疾病的多因素校正风险比分别为1.0695CI0.94-1.19)、1.1895CI1.04-1.35)和1.8495CI1.52-2.22)(趋势P <0.001)。对于HDL的载脂蛋白A1部分,以及更严格的终点定义,对于基线事件,不论低级别炎症或甘油三酯浓度如何。在男女分组中,这些结果与排除基线5年内事件类似。最后,哥本哈根市心脏研究提供了独立结果确认。

研究表明,在普通人群中,HDL胆固醇水平较低与自身免疫性疾病的高风险相关。然而,本研究的观察结果不能确定他们之间存在因果关系。

原始出处:

Christian M. Madsen, Anette Varbo,Low HDL Cholesterol and High Risk of Autoimmune Disease: Two Population-Based Cohort Studies Including 117341 Individuals

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2019-07-23 ZGMFX24A
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