Baidu
map

J Pediatr:先天性巨细胞病毒感染在种族和民族之间的差异研究

2018-06-01 AlexYang MedSci原创

最近,有研究人员评估了种族和民族对先天性巨细胞病毒感染(cCMV)的流行度和临床表现的影响。研究在2007年到2012年进行,共包括了100332名婴儿,他们来自7个医疗中心,并且在医院时进行了cCMV筛选。研究发现,cCMV在群体中的总流行度为每1000人有4.5人患有(95% CI, 4.1-4.9)。黑人婴儿具有最高水平的cCMV流行度(每1000人有9.5人;95% CI, 8.3-11.

最近,有研究人员评估了种族和民族对先天性巨细胞病毒感染(cCMV)的流行度和临床表现的影响。

研究在2007年到2012年进行,共包括了100332名婴儿,他们来自7个医疗中心,并且在医院时进行了cCMV筛选。研究发现,cCMV在群体中的总流行度为每1000人有4.5人患有(95% CI, 4.1-4.9)。黑人婴儿具有最高水平的cCMV流行度(每1000人有9.5人;95% CI, 8.3-11.0),之后为混血婴儿(每1000人有7.8人;95% CI, 4.7-12.0)。在非西班牙白种人婴儿中观察到了显著更低的流行度(每1000人有3人; 95% CI, 2.4-3.6)以及亚洲婴儿(每1000人有1人,95% CI, 0.3-2.5)。在调整了社会经济状态和孕妇年龄之后,黑人婴儿与非西班牙白人婴儿相比更可能患有cCMV(调整后流行度OR,0.7;95% CI, 0.5-1.0)。然而,在种族/民族群组之间,研究人员在有症状的cCMV(9.6%)和感官听力损失(7.8%)上没有发现显著的差异。

最后,研究人员指出,cCMV在种族和民族之间存在着明显的差异,甚至是调整过社会经济状态和孕妇年龄之后仍旧存在。虽然在感染上有显著差异,但是不同的种族和民族之间在新生儿疾病和听力损失比例上是相似的。

原始出处:

Fowler KB, Ross SA, Shimamura M et al. Racial and Ethnic Differences in the Prevalence of Congenital Cytomegalovirus Infection. J Pediatr. 18 May 2018.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1638634, encodeId=9fda1638634a7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 19 10:03:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928337, encodeId=3f94192833eb1, content=<a href='/topic/show?id=00e9286129d' target=_blank style='color:#2F92EE;'>#先天性巨细胞病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28612, encryptionId=00e9286129d, topicName=先天性巨细胞病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Fri Nov 23 20:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727343, encodeId=81731e273436e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 10 08:03:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369374, encodeId=222c13693e453, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502221, encodeId=c5c2150222122, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1638634, encodeId=9fda1638634a7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 19 10:03:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928337, encodeId=3f94192833eb1, content=<a href='/topic/show?id=00e9286129d' target=_blank style='color:#2F92EE;'>#先天性巨细胞病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28612, encryptionId=00e9286129d, topicName=先天性巨细胞病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Fri Nov 23 20:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727343, encodeId=81731e273436e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 10 08:03:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369374, encodeId=222c13693e453, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502221, encodeId=c5c2150222122, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1638634, encodeId=9fda1638634a7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 19 10:03:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928337, encodeId=3f94192833eb1, content=<a href='/topic/show?id=00e9286129d' target=_blank style='color:#2F92EE;'>#先天性巨细胞病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28612, encryptionId=00e9286129d, topicName=先天性巨细胞病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Fri Nov 23 20:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727343, encodeId=81731e273436e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 10 08:03:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369374, encodeId=222c13693e453, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502221, encodeId=c5c2150222122, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=)]
    2019-02-10 feather89
  4. [GetPortalCommentsPageByObjectIdResponse(id=1638634, encodeId=9fda1638634a7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 19 10:03:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928337, encodeId=3f94192833eb1, content=<a href='/topic/show?id=00e9286129d' target=_blank style='color:#2F92EE;'>#先天性巨细胞病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28612, encryptionId=00e9286129d, topicName=先天性巨细胞病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Fri Nov 23 20:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727343, encodeId=81731e273436e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 10 08:03:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369374, encodeId=222c13693e453, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502221, encodeId=c5c2150222122, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=)]
    2018-06-03 huirong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1638634, encodeId=9fda1638634a7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 19 10:03:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928337, encodeId=3f94192833eb1, content=<a href='/topic/show?id=00e9286129d' target=_blank style='color:#2F92EE;'>#先天性巨细胞病毒感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28612, encryptionId=00e9286129d, topicName=先天性巨细胞病毒感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Fri Nov 23 20:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727343, encodeId=81731e273436e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 10 08:03:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369374, encodeId=222c13693e453, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502221, encodeId=c5c2150222122, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Sun Jun 03 13:03:00 CST 2018, time=2018-06-03, status=1, ipAttribution=)]
    2018-06-03 wwzzly

相关资讯

NEJM:letermovir可有效预防造血细胞移植者巨细胞病毒感染

巨细胞病毒疾病对于免疫缺陷患者来说是一种严重的、威胁生命的疾病。尤其是在同种异体造血细胞移植接受者中,巨细胞病毒(CMV)血症发生率达到了50%至60%,其可能进展成CMV疾病。 标准的治疗是静脉给予更昔洛韦或口服制品缬更昔洛韦,或者静脉注射膦甲酸或西多福韦。尽管有效,但是这些治疗具有显著的临床药物特异性影响,包含骨髓移植和肾毒性,使得这些药物在同种异体造血细胞移植接受者中的使用增加了难度。因此

JAMA Pediatrics:早产儿的母乳喂养可能增加巨细胞病毒感染风险

据在线发表于JAMA Pediatrics的一项研究显示,如果极低出生体重儿接受母乳喂养,则感染巨细胞病毒(CMV)的风险显著增加,甚至高于输血。在这项纳入500名极低出生体重儿的研究中,所有参与者的出生体重均低于3.3磅,多数母体有CMV感染病史。随后研究人员对比了母乳喂养和输血的CMV感染风险差异。结果显示,接受母乳喂养的极低出生体重儿中有29人确诊CMV感染,其中27人确定于母乳有关;输血组

J Pediatric Infect Dis Soc:新生儿巨细胞病毒感染听力筛选失败的针对性筛选计划结果

先天性巨细胞病毒(CMV)感染是感官听力损失形成的主要原因。根据法律要求,美国康涅狄格州新生儿听力听力筛选失败的要要进行CMV感染测试。该项针对性的筛选是具有争议的,因为大多数具有先天性CMV感染的儿童都是无症状的,并且CMV相关的听力损失发生较晚。最近,有研究人员利用了唾液聚合酶链式反应(PCR)试验(由尿液PCR确定)来检测CMV。在该研究中,他们报道了第一年的4个筛选计划的结果。研究发现,在

NEJM:乐特莫韦可有效预防异基因造血干细胞移植后巨细胞病毒感染

研究认为乐特莫韦可有效预防异基因造血干细胞移植后巨细胞病毒感染,大部分治疗相关不良事件级别较低

J Virol:人巨细胞病毒感染人神经干细胞初步研究获进展

近期,中科院武汉病毒研究所罗敏华课题组在人神经干细胞体系的建立与人巨细胞病毒(HCMV)感染人神经干细胞初步研究中取得重要进展。相关结果发表于国际病毒学杂志Journal of Virology上。 先天性HCMV感染是导致出生缺陷的最常见病因,主要引起中枢神经系统(CNS)发育紊乱。先天性HCMV发生在早孕期,其后果常常比感染发生于孕晚期更严重,表现为严重脑损伤,包括小脑畸形等。胎脑中HCMV

Baidu
map
Baidu
map
Baidu
map