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Radiology:磁共振成像评估前列腺组织成分来诊断前列腺癌的价值

2018-05-23 shaosai MedSci原创

本研究旨在评估混合多维磁共振成像的分区分析是否可以用来诊断前列腺癌并确定它的侵袭性,并将结果发表在Radiology上。

本研究旨在评估混合多维磁共振成像的分区分析是否可以用来诊断前列腺癌并确定它的侵袭性,并将结果发表在Radiology上。

本研究对二十二例前列腺癌患者进行术前3.0T磁共振成像。通过使用回波时间(47, 75, 100毫秒)和b值分别为0, 750, 1500秒/毫米×2的所有组合,获得混合多维MR成像轴位图像,从而产生与每个体素相关联的3×3阵列数据。通过将混合数据拟合到三区信号模型,计算每个分区的表观扩散系数(ADC)和T2值,计算组织成分间质、上皮和管腔的体积。测量前列腺切除术确诊恶性肿瘤的感兴趣区(n=28)和正常组织(n=71)的体积分数和常规ADC和T2。用受试者工作特征曲线(ROC)分析来评估前列腺癌和良性组织中的各种参数。

结果为与正常组织相比,混合多维磁共振成像显示前列腺癌组织上皮细胞体积分数明显增加(分别为23.2%±7.1 比48.8%±9.2)、管腔体积减小(26.4%±14.1 比14.0%±5.2)、基质体积减小(50.5% ±15.7比37.2%±9.1)。组织成分的体积分数显示相比较于T2值(ρ= -0.292,P =0 .132)和ADC值(ρ= -0.315,P =0 .102),Spearma与Gleason评分相关系数更高(上皮:ρ= 0.652,P = 0.0001;基质:ρ= -0.439,P = 0.020;管腔:ρ= -0.390,P =0.040)。ROC曲线下面积显示区分前列腺癌与正常前列腺时,差异最高的是上皮部分体积(0.991),其次是管腔部分体积(0.800)和基质(0.789)。

结论表明当癌症存在时,前列腺管腔,基质和上皮细胞的体积分数变化显着。这些参数可以通过使用混合多维磁共振成像非侵入性地测量,且有可能提高前列腺癌的诊断并确定其侵袭性。

原始出处:


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1341619, encodeId=6b7713416199f, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri May 25 09:21:00 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318308, encodeId=4e573183087f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri May 25 06:24:46 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318217, encodeId=302131821ef4, content=好知识值得借鉴!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 24 21:01:27 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1341619, encodeId=6b7713416199f, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri May 25 09:21:00 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318308, encodeId=4e573183087f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri May 25 06:24:46 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318217, encodeId=302131821ef4, content=好知识值得借鉴!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 24 21:01:27 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
    2018-05-25 一个字-牛

    学习了谢谢分享

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1341619, encodeId=6b7713416199f, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri May 25 09:21:00 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318308, encodeId=4e573183087f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri May 25 06:24:46 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318217, encodeId=302131821ef4, content=好知识值得借鉴!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 24 21:01:27 CST 2018, time=2018-05-24, status=1, ipAttribution=)]
    2018-05-24 虈亣靌

    好知识值得借鉴!

    0

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