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Cell Rep：NIH研究表明，高活性免疫与衰老性脑疾病有关

2019-01-30 佚名 生物通

高活性免疫衰老神经退行
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NIH/国家神经疾病与中风研究所的一项果蝇研究指出，人体的免疫系统可能在大脑老化损伤中起关键作用。研究结果基于改变Cdk5基因活性后，大脑老化过程加速，导致果蝇更早死亡，并在晚年时期患有飞行或行走障碍，以及更多的神经变性脑损伤迹象。

脑细胞排污系统崩溃,会引发更具破坏性的免疫反应。

NIH/国家神经疾病与中风研究所的一项果蝇研究指出，人体的免疫系统可能在大脑老化损伤中起关键作用。研究结果基于改变Cdk5基因活性后，大脑老化过程加速，导致果蝇更早死亡，并在晚年时期患有飞行或行走障碍，以及更多的神经变性脑损伤迹象。

临床前研究表明，Cdk5是对大脑早期发育很重要的基因，可能与神经退行性疾病有关。新研究发表在Cell Reports，文中，作者认为改变Cdk会导致多巴胺释放神经元死亡，对老年果蝇大脑影响尤其严重。通常情况，帕金森症损害人类相同类型细胞。果蝇研究进一步指出，神经元丢失是因为Cdk减缓了细胞自噬，或者说是细胞的排污处理系统，一种受控制的将受损细胞从体内清除的方式，从而触发免疫系统攻击自身神经元。

免疫系统攻击是一个比自噬更混乱更扩散的过程。通过基因修复排污系统或阻断免疫系统反应，就可以阻止Cdk变化引起的多巴胺神经元减少。

作者得出结论，这种连锁反应的根本是自噬紊乱引发了更广泛的破坏性免疫反应，这些反应可能存在于几种人类神经退行性疾病中，研究人员希望从中寻找新的治疗目标和策略。

原始出处：Shukla AK1, Spurrier J2, Kuzina I1, Giniger E3. Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5. Cell Rep. 2019 Jan 2;26(1):131-144.e4.

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    2019-12-26 zhaozhouchifen

    #Cell#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1871122, encodeId=f2f418e112249, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Dec 26 16:02:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1672138, encodeId=cf1c16e21382b, content=<a href='/topic/show?id=adfd8494496' target=_blank style='color:#2F92EE;'>#脑疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84944, encryptionId=adfd8494496, topicName=脑疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62f626885922, createdName=chendoc251, createdTime=Sun Jul 14 11:02:00 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961399, encodeId=ef4f1961399a6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Aug 17 08:02:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536923, encodeId=785915369232a, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Fri Feb 01 12:02:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359652, encodeId=7c613596520c, content=向科研人员致敬！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5171668917, createdName=坚强007, createdTime=Thu Jan 31 10:25:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
    2019-07-14 chendoc251

    #脑疾病#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1871122, encodeId=f2f418e112249, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Dec 26 16:02:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1672138, encodeId=cf1c16e21382b, content=<a href='/topic/show?id=adfd8494496' target=_blank style='color:#2F92EE;'>#脑疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84944, encryptionId=adfd8494496, topicName=脑疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62f626885922, createdName=chendoc251, createdTime=Sun Jul 14 11:02:00 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961399, encodeId=ef4f1961399a6, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Aug 17 08:02:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536923, encodeId=785915369232a, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Fri Feb 01 12:02:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359652, encodeId=7c613596520c, content=向科研人员致敬！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5171668917, createdName=坚强007, createdTime=Thu Jan 31 10:25:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
    2019-08-17 维他命

    #CEL#

    0

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    2019-02-01 宋威

    #NIH#

    0

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    2019-01-31 坚强007

    向科研人员致敬！！！

    0

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