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SCI REP:多囊卵巢综合征中维生素D与肾上腺代谢和炎症标志物的关系

2019-03-09 不详 MedSci原创

维生素D缺乏与多囊卵巢综合征(PCOS)的代谢改变有关。同样,肾上腺轴的过度活化也可以与PCOS发展相关联。因此,本项研究的目的是建立维生素D和肾上腺参数与PCOS中代谢改变和炎症标志物之间的关系。

背景及目的:
维生素D缺乏与多囊卵巢综合征(PCOS)的代谢改变有关。同样,肾上腺轴的过度活化也可以与PCOS发展相关联。因此,本项研究的目的是建立维生素D和肾上腺参数与PCOS中代谢改变和炎症标志物之间的关系。

方法:
研究人员招募了73名PCOS患者和33名健康对照组患者,采用血清检验25-羟基维生素D(25-OH-D),生物可利用的睾酮(TT和bioT),雄烯二酮(A4),SHBG,皮质醇,胰岛素和C-反应蛋白(hs-CRP)的含量。

结果:
除SHBG和25-OH-D较低外,PCOS患者所有参数均高于对照组。二元回归分析显示TT,bioT,胰岛素与体重指数和腰围无关,但SHBG,hs-CRP,LAP和25-OH-D与体重和脂肪分布有关。二元logistic回归分析显示皮质醇和25-OH-D可能与PCOS发展有关。LAP与胰岛素,HOMA和hs-CRP之间的相关性证实它是代谢并发症的良好指标。

结论
本项研究结果表明,多囊卵巢综合征中维生素D的缺乏与PCOS患者的症状严重程度有关,且SHBG,hs-CRP,LAP和25-OH-D与体重和脂肪分布有关。

原始出处:

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