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J Craniofac Surg：维生素E可促进牵张成骨中的骨形成

2019-06-30 不详 网络

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牵张成骨（DO）的长期巩固期可能导致疼痛，感染，骨折，瘢痕形成，畸形愈合和延迟愈合等并发症。本研究旨在评估下颌骨DO期间全身维生素E应用对兔模型新骨再生的影响。 选择16只成年雄性8月龄的新西兰兔用牵引器进行下颌骨延长研究。在5天的潜伏期后，以0.5mm / 12小时的速率激活牵开器，持续7天。从手术开始，实验动物腹膜内接受200mg / kg的α-生育酚注射7天。在30天的巩固期后，处死兔子。获

牵张成骨（DO）的长期巩固期可能导致疼痛，感染，骨折，瘢痕形成，畸形愈合和延迟愈合等并发症。本研究旨在评估下颌骨DO期间全身维生素E应用对兔模型新骨再生的影响。

选择16只成年雄性8月龄的新西兰兔用牵引器进行下颌骨延长研究。在5天的潜伏期后，以0.5mm / 12小时的速率激活牵开器，持续7天。从手术开始，实验动物腹膜内接受200mg / kg的α-生育酚注射7天。在30天的巩固期后，处死兔子。获得加长的下颌骨并进行双能X射线吸收测定（DXA），放射学和组织形态学分析。

结果显示，在DXA分析期间，实验组中的骨矿物质密度和骨矿物质含量值铭心高于对照组。与对照组相比，实验组的兔在成骨细胞，破骨细胞，血管数和新形成的骨区域方面具有统计学上更高的分数。

总之，本研究的结果表明，在DO期间施用全身性维生素E可以刺激兔子中的新骨形成，从而缩短治疗时间。

原始出处：

Akçay H, Kuru K, et al., Vitamin E Promotes Bone Formation in a Distraction Osteogenesis Model. J Craniofac Surg. 2019 Jun 20. doi: 10.1097/SCS.0000000000005685.

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    2019-10-17 夏天与十三菇凉

    #FAC#

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    2019-11-17 ms3046638856685384

    #牵张成骨#

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    2019-07-02 zhaojie88

    #成骨#

    0

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    2019-07-02 marongnuan

    #维生素E#

    0

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    2019-07-01 龙胆草

    学习谢谢分享

    0

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    2019-07-01 122e052cm96暂无昵称

    好

    0

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