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Am J Obstet Gynecol:女人不能做肉食动物 否则子宫内膜异位症风险来报复

2018-09-06 吴星 环球医学

子宫内膜异位症是一种良性的雌激素依赖性妇科疾病,育龄女性的患病率约为10%。其病因尚未完全知晓。饮食或可通过影响甾体激素,从而影响子宫内膜异位症的发生风险。例如,红肉可降低性激素结合球蛋白(SHBG)并增加雌二醇浓度。

子宫内膜异位症是一种良性的雌激素依赖性妇科疾病,育龄女性的患病率约为10%。其病因尚未完全知晓。饮食或可通过影响甾体激素,从而影响子宫内膜异位症的发生风险。例如,红肉可降低性激素结合球蛋白(SHBG)并增加雌二醇浓度。

仅有2项病例对照研究,考察了肉类产品摄入与子宫内膜异位症风险之间的相关性。但这2项研究,结果也不一致。

2018年8月,美国学者在《Am J Obstet Gynecol》上发表的一项前瞻性队列研究,旨在进一步确定较多摄入红肉、家禽、鱼肉和海产品,是否与子宫内膜异位症风险增加相关。

前瞻性护士健康研究II中总共有81908名参与者,从1991年随访至2013年。通过每4年1次的食品频率调查问卷评估饮食。使用Cox成比例风险模型计算率比和95%置信区间(CI)。

在1019294人-年的随访期内,腹腔镜确诊3800例子宫内膜异位症。

女性每天摄入>2次红肉,其子宫内膜异位症发生风险比每周摄入≤1次的女性高56%。该相关性在未加工红肉中最强烈,尤其在未报告不孕的女性中。

摄入加工红肉最多的女性人群,子宫内膜异位症风险也较高。

家禽、鱼、贝类和鸡蛋的摄入,与子宫内膜异位症风险不相关。

这项在美国绝经前护士中进行的前瞻性分析表明,红肉摄入是子宫内膜异位症重要且可修正的风险因素,尤其在未报告不孕的子宫内膜异位症女性中。因此,她们更可能表现出疼痛症状。

设计良好的子宫内膜异位症女性饮食干预相关研究,有助于进一步证实这些结果。

这一在绝经前女性中进行的前瞻性队列中,研究者观察到,加工和未加工的红肉与腹腔镜确诊的子宫内膜异位症风险增加相关。这种相关性在从未报告不孕的女性中最为密切。

子宫内膜异位症是不孕不育的罪魁祸首,还可引起痛经,影响生活质量。因此,女性朋友还是最好不要做“肉食动物”,无肉不欢!

血红素铁摄入也与子宫内膜异位症的风险相关,部分解释了红肉摄入与子宫内膜异位症相关的原因。

专家点评:该种发生风险是否与肉制品的处理方式相关?未加工的红肉提示我们在设计试验时,应当考虑该种因素。

原始出处:

Yamamoto A, Harris HR, Vitonis AF, et.al. A prospective cohort study of meat and fish consumption and endometriosis risk. Am J Obstet Gynecol. 2018 Aug;219(2):178.e1-178.e10. doi: 10.1016/j.ajog.2018.05.034. Epub 2018 Jun 2.

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    2019-05-11 yhy100200
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    2018-11-03 李小猫

    学习了

    0

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    2018-09-11 1371f63f74m

    学习了!

    0

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