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Allergy：循环25羟维生素D、鼻咽部气道代谢组和细支气管炎严重程度的关系！

2018-01-10 xing.T MedSci原创

25OHD气道代谢组细支气管炎严重程度
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基于多中心的研究数据，维生素D代谢产物与毛细支气管炎的严重程度风险相关。

循环25羟维生素D（25OHD）水平较低是急性呼吸道感染的危险因素（例如，儿童毛细支气管炎）。然而，关于循环25OHD水平与靶器官-如气道-下游多功能分子以及与临床结局之间的关系却尚不明确。近日，过敏性疾病领域权威杂志Allergy上针对这一问题发表了一篇研究文章。

在这项多中心前瞻性研究中，纳入的婴儿（年龄＜1岁）为因毛细支气管炎而住院的患儿，研究人员测量了血清中25OHD水平和检测了144份鼻咽部气道样本的代谢组学谱。

在254个确定的代谢产物中，研究人员确定了一组与较低血清25OHD和较高维生素D结合蛋白水平相关的20个代谢产物。在这些代谢产物中，9种代谢物与使用正压通气的风险较高显著相关。这些代谢产物为炎性脂肪酸酯化的甘油磷脂（棕榈酸、硬脂酸、亚油酸、花生四烯酸）、神经鞘磷脂、α羟基异戊酸、2-羟基丁酸酯和3-（4-羟基苯基）乳酸（所有FDR＜0.05）。

基于多中心的研究数据表明，维生素D代谢产物与毛细支气管炎的严重程度风险相关。

原始出处：

Kohei Hasegawa,et al. CCirculating 25-hydroxyvitamin D, nasopharyngeal airway metabolome, and bronchiolitis severity.Allergy. 2018. http://onlinelibrary.wiley.com/doi/10.1111/all.13379/full

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    2018-02-14 yinhl1986

    #鼻咽部#

    0

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    2018-05-24 zjubiostat

    #支气管#

    0

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    2018-09-11 huangdf

    #细支气管#

    0

  4. 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createdTime=Wed Jan 10 09:00:15 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277090, encodeId=d2d22e709013, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 10 07:21:39 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-02-26 kcb080

    #细支气管炎#

    0

  5. 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    2018-01-11 膀胱癌

    #ALL#

    0

  6. 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createdTime=Wed Jan 10 09:00:15 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277090, encodeId=d2d22e709013, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 10 07:21:39 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-11 ms6897892027066920

    #代谢组#

    0

  7. 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createdTime=Wed Jan 10 09:00:15 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277090, encodeId=d2d22e709013, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 10 07:21:39 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 明天jing

    代谢组学是热点，它反映疾病的终极状态，通过代谢组学可以反向知道生命体的活动特点，只是目前代谢组成分太复杂，背后的机制仍然不完全清楚而已。

    0

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createdTime=Wed Jan 10 09:00:15 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277090, encodeId=d2d22e709013, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 10 07:21:39 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 明月清辉

    谢谢分享.学习了

    0

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createdTime=Wed Jan 10 09:00:15 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277090, encodeId=d2d22e709013, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 10 07:21:39 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 龙胆草

    学习谢谢分享

    0

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GetPortalCommentsPageByObjectIdResponse(id=277127, encodeId=38ca2e712704, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 10 09:03:44 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277116, encodeId=8f2f2e7116d5, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Jan 10 09:00:15 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277090, encodeId=d2d22e709013, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Jan 10 07:21:39 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 榄枷檬

    谢谢分享

    0

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