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ERJ Open Res:短期吸入温盐水雾化气对非囊性纤维化支气管扩张患者的影响

2020-02-19 不详 网络

非囊性纤维化支气管扩张症倡导分泌清除,但在临床治疗中常常被忽略。本研究旨在探讨经超声加温雾化器吸入0.9%生理盐水对稳定的非囊性纤维化支气管扩张性脓性痰患者的影响。研究纳入了27名稳定患者,该试验包括每天3个月的UNW气雾剂治疗与每天3个月的口服祛痰药治疗。结果是生活质量(通过莱斯特咳嗽问卷(LCQ)评估),痰液特征,肺功能,6分钟步行距离(6MWD)和急性发作频率。结果显示,与基线相比,UNW可

非囊性纤维化支气管扩张症倡导分泌清除,但在临床治疗中常常被忽略。本研究旨在探讨经超声加温雾化器吸入0.9%生理盐水对稳定的非囊性纤维化支气管扩张性脓性痰患者的影响。

研究纳入了27名稳定患者,该试验包括每天3个月的UNW气雾剂治疗与每天3个月的口服祛痰药治疗。结果是生活质量(通过莱斯特咳嗽问卷(LCQ)评估),痰液特征,肺功能,6分钟步行距离(6MWD)和急性发作频率。

结果显示,与基线相比,UNW可使痰液粘度,痰液颜色,LCQ得分和6MWD显着改善(p <0.05),而UNW的痰液颜色,LCQ得分,6MWD和鼓气能力的改善明显优于经治疗的患者口服祛痰药(p <0.05)。肺功能,痰细胞学分类及痰中炎症因子治疗无明显差异。

综上所述,该研究结果表明,在非囊性纤维化支气管扩张症中使用UNW气雾剂疗法具有较小但显著的益处。但是,UNW不能改善炎症程度。

原始出处:

Zhong L, Xiong Y, et al., Effect of short-term inhalation of warm saline atomised gas on patients with non-cystic fibrosis bronchiectasis. ERJ Open Res. 2020 Feb 10;6(1). pii: 00130-2019. doi: 10.1183/23120541.00130-2019. eCollection 2020 Jan.

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    2020-07-22 wolongzxh
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    2020-10-29 feather89
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1675926, encodeId=7cb516e592680, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Wed Jul 22 02:46:00 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684826, encodeId=e655168482618, content=<a href='/topic/show?id=794754e74f4' target=_blank style='color:#2F92EE;'>#扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54774, encryptionId=794754e74f4, topicName=扩张)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Aug 26 11:46:00 CST 2020, time=2020-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892220, encodeId=85371892220f2, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Wed Jun 03 11:46:00 CST 2020, time=2020-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728308, encodeId=5d6b1e2830889, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Oct 29 00:46:00 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997575, encodeId=d840199e575eb, content=<a href='/topic/show?id=14c89935e4b' target=_blank style='color:#2F92EE;'>#非囊性纤维化支气管扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99357, encryptionId=14c89935e4b, topicName=非囊性纤维化支气管扩张)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6ac207, createdName=xlwang2691, createdTime=Thu Jul 30 08:46:00 CST 2020, time=2020-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457751, encodeId=2160145e7518e, content=<a href='/topic/show?id=e2d1988611e' target=_blank style='color:#2F92EE;'>#雾化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98861, encryptionId=e2d1988611e, topicName=雾化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Fri Feb 21 08:46:00 CST 2020, time=2020-02-21, status=1, ipAttribution=)]
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