CLIN CANCER RES：血小板通过上调IL-1β促进多发性骨髓瘤进展

2018-06-07 MedSci MedSci原创

实体肿瘤细胞与血小板之间的作用会促进肿瘤进展和转移。但是，血小板在血液学肿瘤中的作用尚不清楚。CLIN CANCER RES近期发表了一篇文章，研究多发性骨髓瘤患者血小板活化状态与临床分期的关系以及血小板在多发性骨髓瘤进展中的作用。

实体肿瘤细胞与血小板之间的作用会促进肿瘤进展和转移。但是，血小板在血液学肿瘤中的作用尚不清楚。CLIN CANCER RES近期发表了一篇文章，研究多发性骨髓瘤患者血小板活化状态与临床分期的关系以及血小板在多发性骨髓瘤进展中的作用。

作者收集了健康志愿者和多发性骨髓瘤患者的血小板。使用流式细胞术和透射电镜检测血小板活化状态。使用多发性骨髓瘤细胞系评估血小板对多发性骨髓瘤细胞增殖的影响。对细胞系进行RNA测序研究多发性骨髓瘤细胞-血小板相互作用的分子机制，并通过CRISPR/Cas9敲除进行验证。研究结果表明，多发性骨髓瘤患者的血小板高度活化。RNA测序表明多发性骨髓瘤患者血小板有关基因增加。体外实验中，血小板促进多发性骨髓瘤细胞增殖，体内实验中血小板有助于肿瘤骨髓植入。与血小板共培养的多发性骨髓瘤细胞系IL-1β上调，IL-1β敲除的多发性骨髓瘤细胞系可以消除血小板对细胞增殖及骨髓植入的影响。

文章最后认为，多发性骨髓瘤患者的血小板在疾病进展过程中是高度活化的。IL-1β对血小板介导的多发性骨髓瘤进展至关重要，可以作为潜在的治疗靶点。

原始出处：

Satoshi Takagi,Shokichi Tsukamoto,et al.Platelets Enhance Multiplt Myeloma Progression via IL-1β Upregulation.CLIN CANCER RES.May 2018 doi:10.1158/1078-0432.CCR-17-2003

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2019-03-22 jml2009

#多发性#

62 0
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2018-06-08 rgjl

#IL-1β#

0 0
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2018-06-08 jjjiang0202

#IL-1#

74 0
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2018-06-07 漪佩飞飞

???!(??????)??好好好

83 0
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2018-06-07 flysky120

血小板在肿瘤中的作用

127 0
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2018-06-07 1ddf0692m34(暂无匿称)

学习了.长知识

0 0
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2018-06-07 龙胆草

学习谢谢分享

0 0
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2018-06-07 smartxiuxiu

好

88 0
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2018-06-07 kafei

学习了谢谢

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