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Hypertension:减少交通相关空气污染对血压的影响

2021-01-25 MedSci原创 MedSci原创

降低室内TRAP浓度可以有效防止急性SBP升高。

暴露于交通相关的空气污染(TRAP)可能会增加高速公路附近居民的血压(BP)和高血压的患病率。相对较少的研究调查减少TRAP暴露对短期BP变化的影响。近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员评估了通过使用独立的高效微粒阻挡过滤器(HEPA)并限制通过门窗的渗透来降低室内TRAP浓度是否能有效防止急性(即在数小时内)的BP升高。

研究人员采用3期交叉设计,77名参与者随机参加了3次2小时长的TRAP暴露,间隔时间为1周洗脱期。每名参与者在州际高速公路附近的一个房间里暴露于高、中、低浓度的TRAP环境中。研究人员连续监测了粒子数浓度、炭黑浓度和温度。每10分钟测量一次收缩压(SBP)、舒张压和心率。该研究的结果采用线性混合模型进行分析。该研究的主要结局是暴露开始20分钟后SBP的变化。

SBP随暴露时间的延长而增加,且增加的量与暴露的大小有关。对于低水平暴露SBP均值变化为0.6mmHg(平均粒子数和黑碳浓度为2500颗粒/cm3和149 ng/m3),中等水平暴露SBP均值变化为1.3mmHg(平均粒子数和黑碳浓度为11000颗粒/cm3和409ng/m3)颗粒,高水平暴露SBP均值变化为2.8mmHg(平均粒子数和黑碳浓度为30000颗粒/cm3和826 ng/m3;线性趋势P=0.019)。次要结局、舒张压或心率没有统计学上的显著差异。

综上所述,降低室内TRAP浓度可以有效防止急性SBP升高

原始出处:

Neelakshi Hudda.et al.Effect of Reducing Ambient Traffic-Related Air Pollution on Blood Pressure A Randomized Crossover Trial.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.15580

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    2021-08-02 feather89
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    2021-01-27 yuandd
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    2021-01-25 山东尼

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