Baidu
map

转化医学

订阅

MedSci主页 / 所有栏目 / 转化医学

CLIN CHEM LAB MED：比较外周血和骨髓中BCR-ABL1？

2020-08-05 MedSci原创 MedSci原创

外周血；骨髓；BCR-ABL1
关注

使用定量聚合酶链反应(PCR)监测BCR-ABL1的分子反应(MR)是指导酪氨酸激酶抑制剂治疗和慢性髓系白血病(CML)患者长期随访的关键工具。

使用定量聚合酶链反应(PCR)监测BCR-ABL1的分子反应(MR)是指导酪氨酸激酶抑制剂治疗和慢性髓系白血病(CML)患者长期随访的关键工具。对MR监测结果根据国际标准(IS)进行了标准化，定义最佳反应和治疗失败的具体时间依赖分子已被纳入治疗建议。在CML中使用外周血（PB）代替骨髓（BM）抽吸物监测MR的常规做法受到质疑。一些研究描述了成对的PB和BM标本中BCR-ABL1水平之间的差异。在此项回顾性单中心研究中，研究人员检测了283例CML患者的631对PB和BM样本，使用标准化定量逆转录(qRT)-PCR检测BCR-ABL1 IS。

研究结果显示，BCR-ABL1 IS结果总体上有较好的一致性，在主要MR的CML患者样本中，可以观察到PB中BCR-ABL1 IS水平系统性升高的趋势。这种差异在接受伊马替尼治疗至少1年的患者中最为明显。重要的是，与PB抽吸物相比，当在PB中评估BCR-ABL1IS时，差异导致深部MR率显著降低。

综上所述，数据表明，在CML患者中，PB对深部MR的分类比BM更为严格。研究人员的研究支持了目前主要使用铅对慢性粒细胞白血病进行长期分子随访监测的做法。

原始出处：

Georg Greiner，Franz Ratzinger，Comparison of BCR-ABL1 quantification in peripheral blood and bone marrow using an International Scale-standardized assay for assessment of deep molecular response in chronic myeloid leukemia

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1956481, encodeId=c8b819564812b, content=<a href='/topic/show?id=002d32834b' target=_blank style='color:#2F92EE;'>#BCR-ABL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3283, encryptionId=002d32834b, topicName=BCR-ABL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=951d2500061, createdName=12498717m66(暂无昵称), createdTime=Tue Nov 03 10:48:12 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578564, encodeId=77b415e85646c, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Fri Aug 07 00:48:12 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610636, encodeId=257b1610636b6, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 07 00:48:12 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
    2020-11-03 12498717m66(暂无昵称)

    #BCR-ABL1#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1956481, encodeId=c8b819564812b, content=<a href='/topic/show?id=002d32834b' target=_blank style='color:#2F92EE;'>#BCR-ABL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3283, encryptionId=002d32834b, topicName=BCR-ABL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=951d2500061, createdName=12498717m66(暂无昵称), createdTime=Tue Nov 03 10:48:12 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578564, encodeId=77b415e85646c, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Fri Aug 07 00:48:12 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610636, encodeId=257b1610636b6, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 07 00:48:12 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
    2020-08-07 ms3994565386320060

    #外周血#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1956481, encodeId=c8b819564812b, content=<a href='/topic/show?id=002d32834b' target=_blank style='color:#2F92EE;'>#BCR-ABL1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3283, encryptionId=002d32834b, topicName=BCR-ABL1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=951d2500061, createdName=12498717m66(暂无昵称), createdTime=Tue Nov 03 10:48:12 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578564, encodeId=77b415e85646c, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Fri Aug 07 00:48:12 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610636, encodeId=257b1610636b6, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 07 00:48:12 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
    2020-08-07 ms3994565386320060

    #Med#

    0

Baidu
map
Baidu
map
Baidu
map