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Prog Retin Eye Res:视网膜成像研究痴呆和中风

2017-03-17 luowenbo MedSci原创

随着预期寿命的增加,患有常见的与年龄相关的脑疾病,包括神经退行性疾病(如:痴呆症)和脑血管疾病(如:中风)的人数预计将大幅增长。目前,神经影像学检查(如:核磁共振成像)可能无法检测到的老年痴呆症和中风的细微亚临床病变(分辨率<100-500mum),因而迫切需要其他的能够检测这些细微亚临床病变的辅助手段。

视网膜成像研究痴呆和中风

随着预期寿命的增加,患有常见的与年龄相关的脑疾病,包括神经退行性疾病(如:痴呆症)和脑血管疾病(如:中风)的人数预计将大幅增长。目前,神经影像学检查(如:核磁共振成像)无法检测到老年痴呆症和中风的细微亚临床病变(分辨率<100-500mum),因而迫切需要其他的能够检测这些细微亚临床病变的辅助手段。

视网膜在解剖结构、胚胎发育与生理上与大脑相似,因此可作为特殊而可行的"窗口"用于研究大脑各部分的关联与细微亚临床病理改变可能的后果。视网膜组件如微脉管系统和视网膜神经节细胞轴突等,可以通过不同视网膜成像技术进行无创性检查,例如眼底摄影和光学想干断层成像术。而且视网膜成像的发展,可能能为脑血管神经退行性病变过程提供新的、潜在的、目前神经影像所不能提供的重要病变依据。

本文概述当前视网膜成像在痴呆与中风研究中的应用,并讨论先进视网膜成像技术和其未来发展方向,旨在评估视网膜成像是否能作为痴呆和中风研究的补充检测手段。

原文出处:

Cheung, Carol Yim-Lui,et al.Imaging retina to study dementia and stroke.Prog Retin Eye Res.2017VN.

本文系梅斯医学(MedSci)原创编译,转载须授权!

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    2017-11-15 ysjykql
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    2017-03-18 zutt
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    2017-03-18 sunylz
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