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ARD:EULAR对风湿性和肌肉骨骼疾病心血管风险管理的建议,包括系统性红斑狼疮和抗磷脂综合征

2022-06-26 彼岸河边草 MedSci原创

痛风、血管炎、系统性硬化症(SSc)、肌炎、混合性结缔组织病(MCTD)、干燥综合征(SS)、系统性红斑狼疮(SLE)和抗磷脂综合征(APS)需要定期筛查和管理可改变的的心血管风险因素和患者教育。

目的为痛风、血管炎、系统性硬化症(SSc)、肌炎、混合性结缔组织病(MCTD)、干燥综合征(SS)、系统性红斑狼疮(SLE)和抗磷脂综合征(APS)的心血管风险(CVR)管理制定建议。

方法:遵循欧洲抗风湿病联盟(EULAR)标准化程序,一个多学科工作组根据系统文献回顾和专家意见制定了CVR预测和管理建议。

结果四个首要原则强调需要定期筛查和管理可改变的CVR因素和患者教育。制定了19 项建议(11 项针对痛风、血管炎、SScMCTD、肌炎、SS8 项针对 SLEAPS),涵盖三个主题:(1CVR预测工具; (2)对传统CVR因素的干预和(3)对疾病相关CVR因素的干预。由于缺乏高质量的证据,一些陈述依赖于专家意见。由于缺乏经过验证的风湿性疾病特异性工具,建议使用通用CVR预测工具。痛风患者应避免使用利尿剂,SSc患者应避免使用β受体阻滞剂,SLE患者应考虑将血压目标设定为<130/80 mm Hg血脂管理应遵循一般人群指南,SLEAPS和大血管炎中使用抗血小板药物应遵循之前的EULAR建议建议痛风患者的血清尿酸水平<0.36 mmol/L (<6 mg/dL)SLE和血管炎患者的疾病活动控制和糖皮质激素剂量最小化。在SLE中推荐使用羟氯喹,因为它也可能降低 CVR,而SLE中的特定免疫抑制治疗或痛风中的降尿酸治疗与降低CVR相关。

结论:这些建议可以指导临床实践和未来研究,以改善风湿性和肌肉骨骼疾病的心血管风险管理。

出处:Drosos GC, Vedder D, Houben E, et al. EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome. Annals of the Rheumatic Diseases 2022;81:768-779.

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  5. 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    2022-06-26 zhouqu_8
  6. 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    2022-06-26 muzishouyi
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