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J Ethnopharmacol：五味子属植物或可治疗神经系统疾病

2014-04-11 张雯雯 中国科学报

五味子神经系统疾病
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近日，中科院昆明植物研究所罗怀容和孙汉董研究组合作发现，五味子属三萜类化合物的神经药理活性，可促进脑源性神经营养因子的表达，为该化合物的生物活性研究提供了新思路。研究成果在线发表于《民族药理学》（Journal of Ethnopharmacology）杂志。 五味子属植物除含有丰富的木脂素类化合物外，还含有结构多样的三萜类化合物，如尼哥纳乐酸等，但在神经药理学上却几乎没有研究报道。 钙离子作

近日，中科院昆明植物研究所罗怀容和孙汉董研究组合作发现，五味子属三萜类化合物的神经药理活性，可促进脑源性神经营养因子的表达，为该化合物的生物活性研究提供了新思路。研究成果在线发表于《民族药理学》（Journal of Ethnopharmacology）杂志。

五味子属植物除含有丰富的木脂素类化合物外，还含有结构多样的三萜类化合物，如尼哥纳乐酸等，但在神经药理学上却几乎没有研究报道。

钙离子作为第二信使把外源信号转变成胞内信号，导致一系列胞内事件和生理反应的发生，如基因表达、细胞凋亡、肌肉收缩等。研究表明，钙离子的信使功能是通过调控细胞内钙离子浓度来实现的。研究者认为，尼哥纳乐酸可能通过钙流促进一氧化氮产生和刺激一种蛋白磷酸化，并进一步影响其基因的表达。

“我们利用神经细胞株PC12细胞研究发现，尼哥纳乐酸呈时间和剂量依赖性，诱导分化PC12细胞内钙离子浓度升高，并去除细胞培养基中钙离子后，尼哥纳乐酸的钙流作用被显著抑制。”罗怀容说。

原始出处：

Yuan XX, Yang LP, Yang ZL, Xiao WL, Sun HD, Wu GS, Luo HR.Effect of nigranoic acid on Ca2+ influx and its downstream signal mechanism in NGF-differentiated PC12 cells.J Ethnopharmacol. 2014 Mar 24. pii: S0378-8741(14)00228-1

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    2014-06-17 chentianping

    #pharma#

    0

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    2015-02-28 jj000001

    #Pharm#

    0

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    2014-08-13 yb6560

    #MAC#

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    2014-07-24 dingxiaobo

    #Pharmacol#

    0

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    2014-11-19 医者仁心

    #植物#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1908162, encodeId=b961190816240, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Tue Jun 17 18:12:00 CST 2014, time=2014-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787140, encodeId=c1271e8714032, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sat Feb 28 18:12:00 CST 2015, time=2015-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995892, encodeId=9dd519958922e, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Aug 13 08:12:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788151, encodeId=76021e881510b, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Jul 24 10:12:00 CST 2014, time=2014-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745163, encodeId=c0d11e45163ac, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Nov 19 01:12:00 CST 2014, time=2014-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282976, encodeId=9d2712829e676, content=<a href='/topic/show?id=4fade445192' target=_blank style='color:#2F92EE;'>#神经系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74451, encryptionId=4fade445192, topicName=神经系统)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Sun Apr 13 10:12:00 CST 2014, time=2014-04-13, status=1, ipAttribution=)]
    2014-04-13 luoxiaog

    #神经系统#

    0

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