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CJASN:HBV且ALT升高的患者易肾功能减退

2012-08-20 范振光 医学论坛报

  中国医学科学院北京协和医院肾内科李学旺教授等研究显示,感染乙型肝炎病毒(HBV)且丙氨酸氨基转移酶(ALT)升高的患者,容易出现肾功能减退。相关论文8月2日在线发表于《美国肾病学会临床杂志》。   研究共纳入6854例年龄在30~75岁间的成人受试者,检测血清HBV表面抗原、ALT、血肌酐、尿蛋白/肌酐比值及慢性肾脏病(CKD)的危险因素。   结果显示,单纯的HBV感染或ALT水

  中国医学科学院北京协和医院肾内科李学旺教授等研究显示,感染乙型肝炎病毒(HBV)且丙氨酸氨基转移酶(ALT)升高的患者,容易出现肾功能减退。相关论文8月2日在线发表于《美国肾病学会临床杂志》

  研究共纳入6854例年龄在30~75岁间的成人受试者,检测血清HBV表面抗原、ALT、血肌酐、尿蛋白/肌酐比值及慢性肾脏病(CKD)的危险因素。

  结果显示,单纯的HBV感染或ALT水平升高(≥非HBV感染、性别特异性人群ALT水平的90%百分位)与肾小球滤过率估算值 [eGFR < 60 ml/(min·1.73 m2)] 降低无明显相关性。与非HBV感染患者相比,HBV感染且ALT升高的患者容易出现eGFR降低(比值比为4.07,P=0.03)。进一步的线性模型统计分析证实,与非HBV感染患者相比,HBV感染且ALT升高患者eGFR平均降低4.5 ml/(min·1.73 m2),P=0.01。研究者还发现,HBV和ALT升高(单独或联合)与蛋白尿或CKD无明显相关性。

链接:

Cai J,Fan X,Mou L,Gao B,Liu X,Li J,Liu L,Wang H,Guo Z,Liu X,Li H,Li X,Li X.Association of Reduced Renal Function with Hepatitis B Virus Infection and Elevated Alanine Aminotransferase.Clin J Am Soc Nephrol 2012 Aug 2

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    2013-05-20 chenhongpeng
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    2013-02-20 ay2000fy
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    2013-06-14 shizhenshan
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    2013-07-18 yese
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    2013-07-12 klivis
  6. [GetPortalCommentsPageByObjectIdResponse(id=1941216, encodeId=65d8194121664, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Mon May 20 07:18:00 CST 2013, time=2013-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783220, encodeId=b2ae1e8322016, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Wed Feb 20 06:18:00 CST 2013, time=2013-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860946, encodeId=b9b41860946ed, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Jun 14 19:18:00 CST 2013, time=2013-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850525, encodeId=d0651850525e1, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Thu Jul 18 06:18:00 CST 2013, time=2013-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836567, encodeId=a789183656ed2, content=<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8524, encryptionId=f9d08524be, topicName=HBV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Fri Jul 12 06:18:00 CST 2013, time=2013-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1769597, encodeId=d6c11e69597ba, content=<a href='/topic/show?id=4900824e432' target=_blank style='color:#2F92EE;'>#肾功能减退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82474, encryptionId=4900824e432, topicName=肾功能减退)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45e738082577, createdName=shuangle, createdTime=Tue Oct 09 10:18:00 CST 2012, time=2012-10-09, status=1, ipAttribution=)]
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