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Hypertension :甜菜根汁的降血压作用

2014-12-04 MedSci MedSci原创

Medscape 11月2日报道了一项有趣的实验结论:日常饮用甜菜根汁可以显著降低血压。甜菜根汁中起作用在于其含有的硝酸盐成分。在这一项为期四周的随机对照的实验里,英国伦敦的Vikas Kapil博士的研究团队观察到了和安慰剂对照组相比每日常规饮用甜菜根汁可以使舒张压和收缩压都显著下降。研究中实验设计是这样的:实验组病人每日饮用250ml甜菜根汁,硝酸盐含量约6.4mmol/day,安慰剂对照组服

Medscape 11月2日报道了一项有趣的实验结论:日常饮用甜菜根汁可以显著降低血压。甜菜根汁中起作用在于其含有的硝酸盐成分。

在这一项为期四周的随机对照的实验里,英国伦敦的Vikas Kapil博士的研究团队观察到了和安慰剂对照组相比每日常规饮用甜菜根汁可以使舒张压和收缩压都显著下降。研究中实验设计是这样的:实验组病人每日饮用250ml甜菜根汁,硝酸盐含量约6.4mmol/day,安慰剂对照组服用等量的甜菜根汁,但是去除了其中的硝酸盐成分。实验期间不管是医院测量,还是家庭,随身血压监测(ABPM),都证实了这一确切效果。

测量还发现实验组血管内皮功能改善,动脉僵硬度下降,对照组服用无硝酸盐的甜菜根汁后以上参数均无改变。

Kapil 说:这是在高血压人群里每日常规补充硝酸盐能长期降压的首个证据,这项发现揭示了高血压治疗领域一个对患者来说尤其便捷,便宜,而又易依从的附加治疗方案。

这项前瞻、单中心、双盲、随机、对照实验包括了64名患者,研究结果发表在2014年11月24日的 Hypertension 杂志上。

医院,家庭,随身24小时血压监测(ABPM)三项数据显示,和基线相比,均显示血压下降。而安慰剂组以上数据均无明显改变。


图1  含硝酸盐甜菜根汁组和无硝酸盐甜菜根汁组的血压情况

除了以上数据,尤为值得注意的,测量显示4周后和安慰剂组相比,实验组内皮功能明显改善(P<0.001),和基线水平比动脉僵硬度下降了0.59m/s(P<0.01),和对照组相比僵硬度小了0.58m/s(P<0.05)。

作者解释道,日常的无机硝酸亚的摄取通过肠肝循环的生物学转化,致使血中硝酸盐的增高。硝酸盐对人体一个显著的血管扩张剂。本研究中日常饮用250ml甜菜根汁可以使血液中硝酸盐含量增加5.5倍。

研究人员说:“不考虑测量的问题,每日通过饮用定量的甜菜根汁来降低血压是具有临床意义的,因为这种方法的降血压能力和标准剂量下单独抗高血压药物的使用的降压效果(9.1/5.5 mm Hg)等同”。

原始出处:


Kapil V, Khambata RS, Robertson A, et al. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. Hypertension 2014; DOI: 10.1161/HYPERTENSIONAHA.114.04675

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    2016-07-05 wxsession27d7949f

    吃吃吃

    0

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    2015-04-29 Boyinsh
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    2014-12-21 feather89
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防控高血压是预防国人因心血管病过早死亡的重要策略 首都医科大学附属北京安贞医院赵冬教授等发现,心血管病死亡对我国人群寿命有很大影响,导致我国人群平均寿命缩短近5年。如其他疾病相关死亡率保持不变,若想将我国人群寿命延长1年,心血管病死亡率至少要从当前水平降低27.4%。(Biomed Environ Sci.2014,27:162) 赵冬教授指出,由于我国农村地区因心血管病死

JAMA Intern Med:装置引导呼吸未能显著降低诊室血压

荷兰一项荟萃分析表明,与音乐治疗和假装置相比,装置引导呼吸(DGB)未能显著降低诊室血压。相关论文9月15日在线发表于《美国医学会杂志·内科学》(JAMA Intern Med)。 研究者检索了Medline、EMBASE、clinicaltrials.gov和Cochrane数据库,并纳入了持续时间最少4周、采用双盲或单盲设计、具有活性对照组的DGB试验。主要转归指标为诊室血压。 结果显示,

陈鲁原:对高血压诊治切点140/90mmHg的质疑

高血压的诊断与降压目标值应该如何确定?此问题国内外的学者已经争论了许多年。本文对目前普遍认同的高血压诊治切点是140/90 mmHg的观点提出如下质疑,以期引发相关临床思考。 1.定义高血压较困难且人为因素多 目前全世界都采用2003年美国预防、检测、评估与治疗高血压全国联合委员会第7次报告(JNC 7)和2007年《欧洲心脏学会/欧洲高血压学会指南》所规定的:所有成年人的正常

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