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CLIN CANCER RES：吉西他滨联合免疫检查点抑制剂可以克服间皮瘤耐药

2018-12-22 MedSci MedSci原创

间皮瘤吉西他滨免疫检查点抑制剂
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间皮瘤是一种侵袭性癌症，几乎没有有效的治疗方案。虽然免疫疗法可能会改善疾病的进程，但往往会出现耐药。因此，克服这种耐药并改善患者的预后至关重要。CLIN CANCER RES近期发表了一篇文章，研究研究免疫检查点抑制剂联合化疗对间皮瘤进行治疗。

间皮瘤是一种侵袭性癌症，几乎没有有效的治疗方案。虽然免疫疗法可能会改善疾病的进程，但往往会出现耐药。因此，克服这种耐药并改善患者的预后至关重要。CLIN CANCER RES近期发表了一篇文章，研究研究免疫检查点抑制剂联合化疗对间皮瘤进行治疗。

作者主要研究这种治疗方案的合理性。研究结果表明，在临床前间皮瘤模型中，吉西他滨联合免疫检查点抑制剂在肿瘤控制和生存方面优于单独的免疫治疗； 然而，在吉西他滨和免疫检查点抑制剂联合方案中加入地塞米松则使得协同性的临床反应失效。此外，吉西他滨联合抗PD-1治疗使得两名对吉西他滨或抗PD-1作为单一疗法出现耐药的间皮瘤患者出现客观临床反应。

文章最后认为，使用吉西他滨和免疫检查点抑制剂联合治疗间皮瘤是可行的，可产生协同的临床效果。

原始出处：

Paulino Tallón de Lara, Virginia Cecconi, et al. Gemcitabine Synergizes with Immune Checkpoint Inhibitors and Overcomes Resistance in a Preclinical Model and Mesothelioma Patients. CLIN CANCER RES. December 2018 doi: 10.1158/1078-0432.CCR-18-1231

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    2019-07-21 jklm09

    #抑制剂#

    0

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    2018-12-24 ms5187542471278033

    #免疫检查点#

    0

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    2018-12-24 1249884fm92暂无昵称

    #间皮瘤#

    0

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    2018-12-23 随梦飞扬

    使用吉西他滨和免疫检查点抑制剂联合治疗间皮瘤是可行的，可产生协同的临床效果。

    0

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    2018-12-23 随梦飞扬

    间皮瘤是一种侵袭性癌症，几乎没有有效的治疗方案

    0

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CLIN CANCER RES：异体肿瘤细胞裂解物冲击自体DC治疗间皮瘤

间皮瘤被认为是一种无免疫原性的肿瘤，对靶向PD-1/PD-L1治疗反应率也很低。之前的研究报道了自体肿瘤裂解物冲击DC的免疫治疗可以增加靶向恶性间皮瘤的T细胞反应。但是，使用自体肿瘤材料限制了大规模临床试验的进行。CLIN CANCER RES近期发表了一篇文章，研究异体裂解物冲击DC的免疫治疗的有效性及在人体内的安全性。

Lancet respir med：Tremelimumab（抗CTLA4单克隆抗体）联合durvalumab（抗PD-L1单克隆抗体）用于间皮瘤的疗效和安全性

Tremelimumab，抗CTLA4单克隆抗体，最初单独用于间皮瘤患者活性良好，但不能提高DETERMINE研究中一线或二线化疗失败的患者的总体存活率（与安慰剂对比）。现研究人员对Tremelimumab联合durvalumab（抗PD-L1单克隆抗体），作为一线或二线疗法，用于恶性间皮瘤的疗效和安全性进行评估。研究人员开展一开放性、非随机的临床II期试验，招募不可手术切除的胸膜或腹膜间皮瘤，予

免疫疗法可改善间皮瘤小鼠的存活率

近日，一项研究指出，两种癌症免疫治疗药物的联合使用能够显著延长侵袭性恶性间皮瘤小鼠模型的存活时间。来自马萨诸塞州总医院（MGH）的疫苗和免疫治疗中心（VIC）的一个研究小组将先前批准用于刺激骨髓移植之前干细胞产生的AMD3100（plerixafor）添加到在研药物VIC-008中使间皮瘤小鼠的生存时间加倍，而这种联合治疗的机制之一即是将免疫抑制性T细胞群体转变为肿瘤抑制性T细胞群体。

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