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Cancer Chemother Pharmacol：大肠杆菌天冬酰胺酶成功治疗过敏反应

2014-06-16 秀荣 医学论坛网

大肠杆菌天冬酰胺酶聚乙二醇化大肠杆菌天冬酰胺酶过敏反应小儿急性淋巴细胞白血病（ALL）
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天冬酰胺酶是小儿急性淋巴细胞白血病(ALL)疗法的一个重要组成部分。然而，天冬酰胺酶引起的过敏反应可通过直接影响天冬酰胺酶的药代动力学或导致天冬酰胺酶治疗中断而影响其疗效。该研究中，美国学者报告了在聚乙二醇化大肠杆菌天冬酰胺酶和欧文氏菌属天冬酰胺酶过敏反应后，成功应用原生大肠杆菌天冬酰胺酶的经验。论文发表于《癌症化疗与药理学》[Cancer Chemotherapy and Pharmacolog

天冬酰胺酶是小儿急性淋巴细胞白血病(ALL)疗法的一个重要组成部分。然而，天冬酰胺酶引起的过敏反应可通过直接影响天冬酰胺酶的药代动力学或导致天冬酰胺酶治疗中断而影响其疗效。该研究中，美国学者报告了在聚乙二醇化大肠杆菌天冬酰胺酶和欧文氏菌属天冬酰胺酶过敏反应后，成功应用原生大肠杆菌天冬酰胺酶的经验。论文发表于《癌症化疗与药理学》[Cancer Chemotherapy and Pharmacology June 2014, 73(6): 1307-1313]。

该病例报告包括在圣裘德儿童研究医院被诊断为B前体细胞白血病、并接受同一治疗方案的2例患者。这2例患者在治疗初期都发生了聚乙二醇化大肠杆菌天冬酰胺酶和欧文氏菌天冬酰胺酶过敏反应，都面临着原生大肠杆菌天冬酰胺酶的应用挑战。在应用天然大肠杆菌天冬酰胺酶治疗期间，采集这2例患者的血清样本进行药代动力学参数评估。

结果为，该研究的2例患者成功应对了天然大肠杆菌天冬酰胺酶的挑战;2例患者都实现了高于疗效水平的天冬酰胺酶血清浓度。

 研究结果表明，一些患者可在聚乙二醇化大肠杆菌天冬酰胺酶过敏反应后给予天然大肠杆菌天冬酰胺酶治疗，并实现该药物的血清疗效浓度。

原始出处

Fernandez CA1, Stewart E, Panetta JC, Wilkinson MR, Morrison AR, Finkelman FD, Sandlund JT, Pui CH, Jeha S, Relling MV, Campbell PK.Successful challenges using native E. coli asparaginase after hypersensitivity reactions to PEGylated E. coli asparaginase.Cancer Chemother Pharmacol. 2014 Jun

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1908165, encodeId=795d1908165d2, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Nov 22 18:11:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788154, encodeId=3cfb1e8815410, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Mar 14 15:11:00 CST 2015, time=2015-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995897, encodeId=c8a1199589eba, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri Jan 30 04:11:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787144, encodeId=c2b11e8714445, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Tue Feb 17 16:11:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336606, encodeId=b838133660654, content=<a href='/topic/show?id=543794035c9' target=_blank style='color:#2F92EE;'>#过敏反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94035, encryptionId=543794035c9, topicName=过敏反应)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKeia4TJeMGvEH3wKKIBNjuHuIic1HDNOB10j4tCd3nbylxkxm6HSMfEaKkSu6OZOak4uZv7UVicsWEg/132, createdBy=bc9a2500116, createdName=zywlvao, createdTime=Wed Jun 18 00:11:00 CST 2014, time=2014-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339965, encodeId=a57f1339965e5, content=<a href='/topic/show?id=e6624383eaf' target=_blank style='color:#2F92EE;'>#大肠杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43837, encryptionId=e6624383eaf, topicName=大肠杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d342500153, createdName=12498bf3m25暂无昵称, createdTime=Wed Jun 18 00:11:00 CST 2014, time=2014-06-18, status=1, ipAttribution=)]
    2014-11-22 chentianping

    #pharma#

    0

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    2015-03-14 dingxiaobo

    #Pharmacol#

    0

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    2015-01-30 yb6560

    #MAC#

    0

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    2015-02-17 jj000001

    #Pharm#

    0

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    2014-06-18 zywlvao

    #过敏反应#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1908165, encodeId=795d1908165d2, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Nov 22 18:11:00 CST 2014, time=2014-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788154, encodeId=3cfb1e8815410, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Mar 14 15:11:00 CST 2015, time=2015-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995897, encodeId=c8a1199589eba, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri Jan 30 04:11:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787144, encodeId=c2b11e8714445, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Tue Feb 17 16:11:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336606, encodeId=b838133660654, content=<a href='/topic/show?id=543794035c9' target=_blank style='color:#2F92EE;'>#过敏反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94035, encryptionId=543794035c9, topicName=过敏反应)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKeia4TJeMGvEH3wKKIBNjuHuIic1HDNOB10j4tCd3nbylxkxm6HSMfEaKkSu6OZOak4uZv7UVicsWEg/132, createdBy=bc9a2500116, createdName=zywlvao, createdTime=Wed Jun 18 00:11:00 CST 2014, time=2014-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339965, encodeId=a57f1339965e5, content=<a href='/topic/show?id=e6624383eaf' target=_blank style='color:#2F92EE;'>#大肠杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43837, encryptionId=e6624383eaf, topicName=大肠杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d342500153, createdName=12498bf3m25暂无昵称, createdTime=Wed Jun 18 00:11:00 CST 2014, time=2014-06-18, status=1, ipAttribution=)]
    2014-06-18 12498bf3m25暂无昵称

    #大肠杆菌#

    0

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