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Lancet Neurol:Pridopidine用于亨廷顿病患者II期疗效不显著

2018-12-18 zhangfan MedSci原创

研究认为,Pridopidine不能改善亨廷顿病患者UHDRS-TMS评分

先前的小规模研究表明,pridopidine可缓解亨廷顿病患者的运动障碍。近日研究人员考察了增加pridopidine剂量对改善亨廷顿病患者的运动障碍的效果及耐受性。

PRIDE-HD研究中,21岁以上的亨廷顿病患者接受剂量递增研究,患者UHDRS-TMS得分25分以上,UHDRS自理能力评估≤90%。患者随机接受45mg、67.5mg、90mg或112.5mg的pridopidine或安慰剂,持续52周。研究的主要终点为治疗26周后 UHDRS-TMS得分变化。

408名患者参与研究,其中安慰剂组82人,45mg组81人,67.5mg组82人,90mg组81人,112.5mg组81人。研究发现,相对于安慰剂任何剂量的Pridopidine均未能显著改善患者26周UHDRS-TMS得分。最常见的不良事件包括腹泻、呕吐、鼻咽炎、跌倒、头痛、失眠和焦虑,治疗导致的严重不良事件包括经常性跌倒(n=5),自杀未遂(n=4),自杀意念(n=3),头部损伤(n=3)和吸入性肺炎(n=3)。

研究认为,Pridopidine不能改善亨廷顿病患者UHDRS-TMS评分

原始出处:


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    2019-03-21 howi
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    2019-07-13 tongyongming
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    2019-09-08 yinhl1978
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    2018-12-18 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2018-12-18 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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