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JCEM:热消融治疗原发性甲状旁腺功能亢进的疗效和安全性分析

2021-04-14 MedSci原创 MedSci原创

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,这项研究旨评估热消融治疗原发性甲状旁腺功能

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,这项研究旨评估热消融治疗原发性甲状旁腺功能亢进(pHPT)的疗效和安全性。

从2015年1月到2020年3月,研究人员回顾性地分析了在4个中心接受热消融治疗的pHPT患者数据。中位随访时间为18.1个月(IQR为6.5-42.2个月)。治愈是指在整个随访期间血钙和甲状旁腺激素(PTH)水平恢复正常,且至少6个月以上。研究人员分析了治疗的技术成功率、疗效和安全性。

研究人员纳入了119例(平均年龄57.2±16.3岁;女性81人)患者,共计134处甲状旁腺结节。甲状旁腺平均最大直径为1.6±0.9cm。96例患者进行微波消融(MWA),23例患者进行射频消融(RFA)。技术成功率为98.3%,治愈率为89.9%。治愈患者与未进行靶病灶消融的患者在最大直径上存在显著差异。

排除pHPT结节直径<0.6cm的患者外,其治愈率为95%。MWA和RFA在6个月的治愈率上没有显著差异(MWA vs. RFA为90.6% vs. 87.0%;χ2=0.275, p=0.699)。12个月时消融区体积缩小率为94.6%,并发症发生率为6.7%(8/119)。除一例患者有持续性声音障碍外,其他症状均在6个月内自行缓解。

由此可见,热消融治疗pHPT有效且安全

原始出处:

Ying Wei.et al.Effectiveness and Safety of Thermal Ablation in the Treatment of Primary Hyperparathyroidism: A Multicenter Study.JCEM.2021.https://doi.org/10.1210/clinem/dgab240

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createdName=huperzia, createdTime=Thu Apr 15 22:44:12 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513936, encodeId=582e15139364e, content=<a href='/topic/show?id=32d33e069ee' target=_blank style='color:#2F92EE;'>#原发性甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Thu Apr 15 22:44:12 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-05-10 smallant2015
  5. 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  6. 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createdName=huperzia, createdTime=Thu Apr 15 22:44:12 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513936, encodeId=582e15139364e, content=<a href='/topic/show?id=32d33e069ee' target=_blank style='color:#2F92EE;'>#原发性甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Thu Apr 15 22:44:12 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-17 achengzhao
  7. 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认可 对于有症状的外周动脉疾病(PAD)患者,腔内血运重建可有效改善症状及保肢率,但存在术后再狭窄的困扰。紫杉醇药物涂层装置(DCB)的设计初衷就是为了解决再狭窄问题以及改善通畅率。

中国科兴新冠疫苗智利Ⅲ期试验初步结果显示良好安全性和免疫原性

智利有关专家团队17日在圣地亚哥举行发布会,介绍了去年11月以来中国科兴公司新冠疫苗在智利进行Ⅲ期临床试验的初步情况,证实科兴疫苗具有良好的安全性和免疫原性。

JCEM:度拉糖肽对老年患者疗效和安全性分析

度拉糖肽对≥65岁和<65岁的患者具类似的疗效和安全性。

Prostate Cancer:纳米体多烯紫杉醇脂悬液在转移去势抵抗性前列腺癌中的多中心、回顾性疗效和安全性研究

最近,有研究人员评估了纳米多烯紫杉醇脂悬液(NDLS,DoceAqualip)在转移去势抵抗性前列腺癌(mCRPC)患者中的疗效和安全性。

Ann Rheum Dis:使用乌帕替尼治疗类风湿性关节炎的安全性

乌帕替尼是一种Janus激酶抑制剂,这项研究分析了治疗中重度类风湿关节炎(RA)时乌帕替尼的安全性。

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