Br J Cancer：胰腺导管腺癌生物标志物——C4BPA

2016-09-26 Moon 译 MedSci原创

因为缺乏早期的特异性诊断标志物，胰腺导管腺癌（PDAC）仍是一种毁灭性的疾病。为了改善这种现状，研究者试图通过蛋白质组学，寻找PDAC的新型生物标志物。通过使用串联质谱标记标签和LC-MS/MS，我们对PDAC患者术前和术后血清进行比较分析，识别PDAC的血清特异性标志物。在验证研究中，我们评估了候选蛋白质的区分能力。对302个蛋白质进行分析后，发现了20个可能作为标志物的蛋白质，

因为缺乏早期的特异性诊断标志物，胰腺导管腺癌（PDAC）仍是一种毁灭性的疾病。为了改善这种现状，研究者试图通过蛋白质组学，寻找PDAC的新型生物标志物。

通过使用串联质谱标记标签和LC-MS/MS，我们对PDAC患者术前和术后血清进行比较分析，识别PDAC的血清特异性标志物。在验证研究中，我们评估了候选蛋白质的区分能力。

对302个蛋白质进行分析后，发现了20个可能作为标志物的蛋白质，选择C4b结合蛋白α链(C4BPA)和多聚免疫球蛋白受体(PIGR)进行进一步的研究。PDAC患者术前与术后相比，血清中C4BPA和PIGR水平更高（P<0.008、P<0.036）。

PDAC患者与健康对照组、胰腺炎患者和其他恶性肿瘤（包括胆道癌（BTC））患者相比，血清中C4BPA水平更高(P<0.001)，但是对PIGR进行分析时，没有发现这种关系。

PDAC患者与非癌症患者相比较时，受试者工作曲线(ROC)下面积分别为：C4BPA 0.860；CA19-9 0.846；C4BPA+CA19-9 0.930。I和II期PDAC vs BTC，C4BPA的AUC为0.912；CA19-9的AUC为0.737。PDAC vs BTC，C4BPA的AUC为0.854；CA19-9的AUC为0.264。

我们已经证明，C4BPA是新型的、可检测早期胰腺癌的血清标志物，同时可以区分其他胃肠道肿瘤。C4BPA能否在临床上作为PDAC的有效指标，还需要将来进一步的研究。

原始出处：

Sogawa K.et al.Identification of a novel serum biomarker for pancreatic cancer, C4b-binding protein α-chain (C4BPA) by quantitative proteomic analysis using tandem mass tags.Br J Cancer. 2016 Sep 22. doi: 10.1038/bjc.2016.295. [Epub ahead of print]

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2016-12-23 zhlpower

#BPA#

51 0
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2017-01-23 hukaixun

#标志物#

35 0
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2016-09-28 zhu_jun9842

#生物标志#

31 0
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2016-09-28 zhu_jun9842

#生物标志#

36 0
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2016-09-27 夫夫子

C4BPA也会变成肿瘤指标

75 0
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2016-09-26 知难而进

继续关注！

64 0
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2016-09-26 知难而进

谢谢分享！

75 0
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2016-09-26 1e0a2178m68(暂无匿称)

非常值得学习，要重视

66 0

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