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Am J Transl Res：KiSS-1可抑制裸鼠鼻咽癌移植瘤的转移

2019-03-25 不详 网络

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鼻咽癌（NPC）是一种起源于鼻咽上皮的头颈部恶性肿瘤，主要在华南及东南亚国家流行。 KiSS-1是一系列癌症中肿瘤转移的抑制剂。我们建立了一个SUNE-1-5-8F细胞亚群（来自人类的NPC细胞系），用KiSS-1基因携带的慢病毒载体进行染色，并用嘌呤霉素选择。用稳定过表达KiSS-1的亚基成功建立BALB / c-nu小鼠移植瘤动物模型。结果显示，移植瘤中KiSS-1过表达的裸鼠移植瘤大小与对照

鼻咽癌（NPC）是一种起源于鼻咽上皮的头颈部恶性肿瘤，主要在华南及东南亚国家流行。 KiSS-1是一系列癌症中肿瘤转移的抑制剂。

我们建立了一个SUNE-1-5-8F细胞亚群（来自人类的NPC细胞系），用KiSS-1基因携带的慢病毒载体进行染色，并用嘌呤霉素选择。用稳定过表达KiSS-1的亚基成功建立BALB / c-nu小鼠移植瘤动物模型。

结果显示，移植瘤中KiSS-1过表达的裸鼠移植瘤大小与对照移植瘤小鼠移植瘤大小无明显差异。我们在肺中检测到转移性肿瘤但在肝脏中未检测到。此外，我们还发现，在移植瘤中KiSS-1过表达的裸鼠中，与对照移植肿瘤小鼠模型相比，肺中的转移性肿瘤极少。

总之，该研究结果表明，KiSS-1可能有利于抑制人NPC的转移。本研究可能对鼻咽癌的治疗有所启发，可能有助于改善鼻咽癌患者的预后。

原始出处：

Wang GM, Liu JF, et al., Inhibition of KiSS-1 on metastasis of nasopharyngeal carcinoma implant tumor in nude mice. Am J Transl Res. 2019 Feb 15;11(2):904-910. eCollection 2019.

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    2019-08-17 ms3025846204744509

    #Transl#

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    2019-11-05 xirongguo

    #移植瘤#

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    2019-08-20 12590712m79暂无昵称

    学习

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    2019-08-18 12590712m79暂无昵称

    学习

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    2019-08-17 12590712m79暂无昵称

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2067422, encodeId=24ee206e4224b, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Aug 17 19:06:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062321, encodeId=f49b2062321ac, content=<a href='/topic/show?id=d576e520959' target=_blank style='color:#2F92EE;'>#移植瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75209, encryptionId=d576e520959, topicName=移植瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=50ba440, createdName=xirongguo, createdTime=Tue Nov 05 03:06:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371544, encodeId=bb0f3e15445f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 20 10:47:58 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371431, encodeId=3f093e1431f3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sun Aug 18 07:19:41 CST 2019, time=2019-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371395, encodeId=bc673e139536, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:22:26 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371394, encodeId=4b3f3e139416, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:21:57 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371285, encodeId=28743e12851d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Thu Aug 15 07:19:01 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371243, encodeId=58273e124313, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Wed Aug 14 09:28:12 CST 2019, time=2019-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371188, encodeId=fb493e11886f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 13 07:11:33 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371156, encodeId=a5003e11569a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Mon Aug 12 14:25:47 CST 2019, time=2019-08-12, status=1, ipAttribution=)]
    2019-08-17 12590712m79暂无昵称

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2067422, encodeId=24ee206e4224b, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Aug 17 19:06:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062321, encodeId=f49b2062321ac, content=<a href='/topic/show?id=d576e520959' target=_blank style='color:#2F92EE;'>#移植瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75209, encryptionId=d576e520959, topicName=移植瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=50ba440, createdName=xirongguo, createdTime=Tue Nov 05 03:06:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371544, encodeId=bb0f3e15445f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 20 10:47:58 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371431, encodeId=3f093e1431f3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sun Aug 18 07:19:41 CST 2019, time=2019-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371395, encodeId=bc673e139536, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:22:26 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371394, encodeId=4b3f3e139416, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:21:57 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371285, encodeId=28743e12851d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Thu Aug 15 07:19:01 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371243, encodeId=58273e124313, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Wed Aug 14 09:28:12 CST 2019, time=2019-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371188, encodeId=fb493e11886f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 13 07:11:33 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371156, encodeId=a5003e11569a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Mon Aug 12 14:25:47 CST 2019, time=2019-08-12, status=1, ipAttribution=)]
    2019-08-15 12590712m79暂无昵称

    学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2067422, encodeId=24ee206e4224b, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Aug 17 19:06:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062321, encodeId=f49b2062321ac, content=<a href='/topic/show?id=d576e520959' target=_blank style='color:#2F92EE;'>#移植瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75209, encryptionId=d576e520959, topicName=移植瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=50ba440, createdName=xirongguo, createdTime=Tue Nov 05 03:06:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371544, encodeId=bb0f3e15445f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 20 10:47:58 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371431, encodeId=3f093e1431f3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sun Aug 18 07:19:41 CST 2019, time=2019-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371395, encodeId=bc673e139536, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:22:26 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371394, encodeId=4b3f3e139416, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:21:57 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371285, encodeId=28743e12851d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Thu Aug 15 07:19:01 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371243, encodeId=58273e124313, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Wed Aug 14 09:28:12 CST 2019, time=2019-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371188, encodeId=fb493e11886f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 13 07:11:33 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371156, encodeId=a5003e11569a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Mon Aug 12 14:25:47 CST 2019, time=2019-08-12, status=1, ipAttribution=)]
    2019-08-14 12590712m79暂无昵称

    学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2067422, encodeId=24ee206e4224b, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Aug 17 19:06:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062321, encodeId=f49b2062321ac, content=<a href='/topic/show?id=d576e520959' target=_blank style='color:#2F92EE;'>#移植瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75209, encryptionId=d576e520959, topicName=移植瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=50ba440, createdName=xirongguo, createdTime=Tue Nov 05 03:06:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371544, encodeId=bb0f3e15445f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 20 10:47:58 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371431, encodeId=3f093e1431f3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sun Aug 18 07:19:41 CST 2019, time=2019-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371395, encodeId=bc673e139536, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:22:26 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371394, encodeId=4b3f3e139416, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:21:57 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371285, encodeId=28743e12851d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Thu Aug 15 07:19:01 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371243, encodeId=58273e124313, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Wed Aug 14 09:28:12 CST 2019, time=2019-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371188, encodeId=fb493e11886f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 13 07:11:33 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371156, encodeId=a5003e11569a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Mon Aug 12 14:25:47 CST 2019, time=2019-08-12, status=1, ipAttribution=)]
    2019-08-13 12590712m79暂无昵称

    学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2067422, encodeId=24ee206e4224b, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Aug 17 19:06:00 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062321, encodeId=f49b2062321ac, content=<a href='/topic/show?id=d576e520959' target=_blank style='color:#2F92EE;'>#移植瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75209, encryptionId=d576e520959, topicName=移植瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=50ba440, createdName=xirongguo, createdTime=Tue Nov 05 03:06:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371544, encodeId=bb0f3e15445f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 20 10:47:58 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371431, encodeId=3f093e1431f3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sun Aug 18 07:19:41 CST 2019, time=2019-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371395, encodeId=bc673e139536, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:22:26 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371394, encodeId=4b3f3e139416, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Sat Aug 17 10:21:57 CST 2019, time=2019-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371285, encodeId=28743e12851d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Thu Aug 15 07:19:01 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371243, encodeId=58273e124313, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Wed Aug 14 09:28:12 CST 2019, time=2019-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371188, encodeId=fb493e11886f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Tue Aug 13 07:11:33 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371156, encodeId=a5003e11569a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82fc2575215, createdName=12590712m79暂无昵称, createdTime=Mon Aug 12 14:25:47 CST 2019, time=2019-08-12, status=1, ipAttribution=)]
    2019-08-12 12590712m79暂无昵称

    学习

    0

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