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Circulation:射血分数降低的心衰该不该进行高强度间歇训练?

2017-01-13 xing.T MedSci原创

在改善左心室重构和有氧能力方面,HIIT并不优于MCT,在心衰患者中的可行性仍然没有解决。

少数研究表明在逆转射血分数降低的心衰(HFrEF)患者心肌重构和增加HFrEF患者有氧能力方面,高强度间歇训练(HIIT)优于中度持续训练(MCT)。近日,心血管领域权威杂志Circulation上发表了一篇研究文章,在这个多中心临床试验中,研究人员比较了12周监督的HIIT、MCT或者推荐的常规锻炼(RRE)的效果。

研究者纳入了261名左室射血分数小于35%、纽约心功能分级为II-III的患者,并将他们随机分保持90-95%最大心率(HRmax)的HIIT组、60-70%HRmax的MCT组或RRE。此后,患者被鼓励继续自行锻炼。研究之初对这些参与者进行临床评估,干预后,并随访52周。该研究的主要终点为从基线到12周的左心室舒张末期内径变化情况。

各组患者在年龄(中位数为60岁)、性别(女性占19%)、缺血性病因(59%)或治疗药物上没有显着差异。从基线到12周,左室舒张末期内径变化在HIIT组和MCT组之间无显著性差异,P=0.45;相比于RRE,HIIT组和MCT组各自的变化值为-2.8mm(-5.2,-0.4;P=0.02)和-1.2mm(-3.6,1.2;P=0.34)。研究者发现峰值摄氧量在HIIT组和MCT组之间也没有差异,P=0.70,但均优于RRE。然而,在随访52周后这些变化不复存在。在监督干预和随访52周期间各组严重不良事件均无统计学差异(HIIT为39%,MCT为25%,RRE为34%,P=0.16)。训练记录显示在监督的HIIT组患者中有51%的患者运动量少于规定目标值,而MCT组80%以上的患者运动量少于规定目标值。

由此可见,在改善左心室重构和有氧能力方面,HIIT并不优于MCT,在心衰患者中的可行性仍然没有解决。

原始出处:

Øyvind Ellingsen,  et al. High Intensity Interval Training in Heart Failure
Patients with Reduced Ejection Fraction
. Circulation. 2017. 


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    2017-01-15 aids219
  5. [GetPortalCommentsPageByObjectIdResponse(id=2085936, encodeId=3b8620859362b, content=<a href='/topic/show?id=545810238258' target=_blank style='color:#2F92EE;'>#高强度间歇训练#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102382, encryptionId=545810238258, topicName=高强度间歇训练)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Mon Aug 07 16:17:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449233, encodeId=82d3144923353, content=<a href='/topic/show?id=2ff746814f0' target=_blank style='color:#2F92EE;'>#射血分数降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46814, encryptionId=2ff746814f0, topicName=射血分数降低)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50105466425, createdName=lmm399, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493341, encodeId=0f1514933419c, content=<a href='/topic/show?id=ff1a4681ee0' target=_blank style='color:#2F92EE;'>#射血分数降低的心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46817, encryptionId=ff1a4681ee0, topicName=射血分数降低的心衰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74979029791, createdName=fusion, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603991, encodeId=0950160399129, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170133, encodeId=95fd1e01338d, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Fri Jan 13 18:20:03 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170115, encodeId=cb171e0115d2, content=非常具有参考价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150601/IMG556BDFD3490274903.jpg, createdBy=6a461618563, createdName=zhoujianyong8416, createdTime=Fri Jan 13 17:16:29 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170071, encodeId=cddd1e007171, content=学习了分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6b0d1671629, createdName=1de11f7fm56(暂无匿称), createdTime=Fri Jan 13 13:12:31 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170054, encodeId=064b1e00546d, content=在改善左心室重构和有氧能力方面,HIIT并不优于MCT,在心衰患者中的可行性仍然没有解决。高强度间歇训练(HIIT)中度持续训练(MCT), beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Jan 13 12:47:05 CST 2017, time=2017-01-13, status=1, ipAttribution=)]
    2017-01-13 thlabcde

    好东西学习了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2085936, encodeId=3b8620859362b, content=<a href='/topic/show?id=545810238258' target=_blank style='color:#2F92EE;'>#高强度间歇训练#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102382, encryptionId=545810238258, topicName=高强度间歇训练)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Mon Aug 07 16:17:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449233, encodeId=82d3144923353, content=<a href='/topic/show?id=2ff746814f0' target=_blank style='color:#2F92EE;'>#射血分数降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46814, encryptionId=2ff746814f0, topicName=射血分数降低)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50105466425, createdName=lmm399, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493341, encodeId=0f1514933419c, content=<a href='/topic/show?id=ff1a4681ee0' target=_blank style='color:#2F92EE;'>#射血分数降低的心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46817, encryptionId=ff1a4681ee0, topicName=射血分数降低的心衰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74979029791, createdName=fusion, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603991, encodeId=0950160399129, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170133, encodeId=95fd1e01338d, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Fri Jan 13 18:20:03 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170115, encodeId=cb171e0115d2, content=非常具有参考价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150601/IMG556BDFD3490274903.jpg, createdBy=6a461618563, createdName=zhoujianyong8416, createdTime=Fri Jan 13 17:16:29 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170071, encodeId=cddd1e007171, content=学习了分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6b0d1671629, createdName=1de11f7fm56(暂无匿称), createdTime=Fri Jan 13 13:12:31 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170054, encodeId=064b1e00546d, content=在改善左心室重构和有氧能力方面,HIIT并不优于MCT,在心衰患者中的可行性仍然没有解决。高强度间歇训练(HIIT)中度持续训练(MCT), beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Jan 13 12:47:05 CST 2017, time=2017-01-13, status=1, ipAttribution=)]
    2017-01-13 zhoujianyong8416

    非常具有参考价值

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2085936, encodeId=3b8620859362b, content=<a href='/topic/show?id=545810238258' target=_blank style='color:#2F92EE;'>#高强度间歇训练#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102382, encryptionId=545810238258, topicName=高强度间歇训练)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Mon Aug 07 16:17:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449233, encodeId=82d3144923353, content=<a href='/topic/show?id=2ff746814f0' target=_blank style='color:#2F92EE;'>#射血分数降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46814, encryptionId=2ff746814f0, topicName=射血分数降低)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50105466425, createdName=lmm399, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493341, encodeId=0f1514933419c, content=<a href='/topic/show?id=ff1a4681ee0' target=_blank style='color:#2F92EE;'>#射血分数降低的心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46817, encryptionId=ff1a4681ee0, topicName=射血分数降低的心衰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74979029791, createdName=fusion, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603991, encodeId=0950160399129, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170133, encodeId=95fd1e01338d, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Fri Jan 13 18:20:03 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170115, encodeId=cb171e0115d2, content=非常具有参考价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150601/IMG556BDFD3490274903.jpg, createdBy=6a461618563, createdName=zhoujianyong8416, createdTime=Fri Jan 13 17:16:29 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170071, encodeId=cddd1e007171, content=学习了分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6b0d1671629, createdName=1de11f7fm56(暂无匿称), createdTime=Fri Jan 13 13:12:31 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170054, encodeId=064b1e00546d, content=在改善左心室重构和有氧能力方面,HIIT并不优于MCT,在心衰患者中的可行性仍然没有解决。高强度间歇训练(HIIT)中度持续训练(MCT), beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Jan 13 12:47:05 CST 2017, time=2017-01-13, status=1, ipAttribution=)]
    2017-01-13 1de11f7fm56(暂无匿称)

    学习了分享谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2085936, encodeId=3b8620859362b, content=<a href='/topic/show?id=545810238258' target=_blank style='color:#2F92EE;'>#高强度间歇训练#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102382, encryptionId=545810238258, topicName=高强度间歇训练)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Mon Aug 07 16:17:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449233, encodeId=82d3144923353, content=<a href='/topic/show?id=2ff746814f0' target=_blank style='color:#2F92EE;'>#射血分数降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46814, encryptionId=2ff746814f0, topicName=射血分数降低)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50105466425, createdName=lmm399, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493341, encodeId=0f1514933419c, content=<a href='/topic/show?id=ff1a4681ee0' target=_blank style='color:#2F92EE;'>#射血分数降低的心衰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46817, encryptionId=ff1a4681ee0, topicName=射血分数降低的心衰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74979029791, createdName=fusion, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603991, encodeId=0950160399129, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Sun Jan 15 02:17:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170133, encodeId=95fd1e01338d, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Fri Jan 13 18:20:03 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170115, encodeId=cb171e0115d2, content=非常具有参考价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150601/IMG556BDFD3490274903.jpg, createdBy=6a461618563, createdName=zhoujianyong8416, createdTime=Fri Jan 13 17:16:29 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170071, encodeId=cddd1e007171, content=学习了分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6b0d1671629, createdName=1de11f7fm56(暂无匿称), createdTime=Fri Jan 13 13:12:31 CST 2017, time=2017-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170054, encodeId=064b1e00546d, content=在改善左心室重构和有氧能力方面,HIIT并不优于MCT,在心衰患者中的可行性仍然没有解决。高强度间歇训练(HIIT)中度持续训练(MCT), beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri Jan 13 12:47:05 CST 2017, time=2017-01-13, status=1, ipAttribution=)]
    2017-01-13 inter158

    在改善左心室重构和有氧能力方面,HIIT并不优于MCT,在心衰患者中的可行性仍然没有解决。高强度间歇训练(HIIT)中度持续训练(MCT)

    0

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