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JACC:低密度脂蛋白胆固醇处于正常水平就安全了?

2017-12-13 MedSci MedSci原创

传统上认为,缺乏心血管危险因素(CVRFs)患动脉粥样硬化的风险低,然而,没有CVRFs的个体仍报道有不良心血管事件的发生。本研究的目的旨在评估分析没有CVRF的个体患亚临床动脉粥样硬化的危险预测因素。本研究纳入了PESA临床试验中无传统心血管危险因素的个体(n = 1,779; 平均年龄为45.0 ± 4.1 岁,女性占 50.3%)。无传统心血管危险因素包括一下几点:不吸烟,血压<140/90

传统上认为,缺乏心血管危险因素(CVRFs)患动脉粥样硬化的风险低,然而,没有CVRFs的个体仍报道有不良心血管事件的发生。本研究的目的旨在评估分析没有CVRF的个体患亚临床动脉粥样硬化的危险预测因素。本研究纳入了PESA临床试验中无传统心血管危险因素的个体(n = 1,779; 平均年龄为45.0 ± 4.1 岁,女性占 50.3%)。无传统心血管危险因素包括一下几点:不吸烟,血压<140/90mm Hg,空腹血糖低于126毫克/分升,总胆固醇<240毫克/分升,低密度脂蛋白胆固醇(LDL-C)<160毫克/分升和高密度脂蛋白胆固醇≥40毫克/分升。其中,血压<120/80 mm Hg,空腹血糖<100毫克/分升,糖化血红蛋白<5.7%,总胆固醇<200毫克/分升的个体定义为最佳亚组(n=740)。评估分析的临床指标包括:超声检测颈动脉、髂股、腹主动脉斑块;冠状动脉钙化;血清标志物;生活方式。最终,发现有49.7%的无传统心血管危险因素的个体患有亚临床动脉粥样硬化(动脉斑块或冠脉钙化)。评估分析结果显示,男性、年龄和LDL-C与动脉粥样硬化呈独立相关性。此外,动脉粥样硬化同样与参与者

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    2018-03-17 hbwxf
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    2017-12-15 戒馋,懒,贪

    谢谢分享学习了

    0

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    2017-12-13 雅文博武

    学习了很多先进的医疗技术

    0

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    2017-12-13 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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    2017-12-13 戒馋,懒,贪

    谢谢分享学习了

    0

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与情绪波动相关的心血管疾病

影视作品及小说中我们常常能看到角色因受到各种事件的刺激导致激动或焦虑情绪,从而出现胸闷、心悸、呼吸困难乃至晕厥的情况。那么从医学上考虑引发这种症状的疾病可能是心梗、缺血性心肌病等,但这些都是有既往病史的,那么没有既往疾病的情况会是什么呢?让我们看看下面的病例吧。病史:患者为一53岁中年女性,平素体健,平常爱好打牌,既往否认高血压及糖尿病病史,否认其他特殊病史及药物过敏史。1个小时前,患者如平时一样

JACC:左房梗塞对心房重塑的影响

目前,对心梗后的左房重塑的认识尚浅。本研究的目的旨在利用心肌梗塞的猪模型来评估左房结构重塑的能力,并阐明左房重塑是如何影响二尖瓣返流的进展。本研究共建立了3个动物模型:1) 近端左回旋支(LCX)包括左房分支冠状动脉闭塞(左房梗塞组);2)近端左回旋支(LCX)不包括左房分支冠状动脉闭塞(LCx组);3)左前降支(LAD)闭塞(LAD组)。通过心脏磁共振扫描对左房、左室重塑和缺血性二尖瓣返流进行评

JACC:依普利酮可减少房颤负担,但不影响心房电重构

醛固酮抑制剂依普利酮(EPL)可以减少收缩型心衰患者房颤的发病风险,然而,其具体机制尚未阐明。本研究将34只房性心动过速的山羊(13 ± 1周)随机分成每日口服EPL组(n=19)和糖片对照组(n=14),主要终点事件是连续七天的房颤(n=29)或持续23周的心动过速(n=5)。结果显示,EPL可以明显减少房颤发展过程中左房的扩张率。与对照组相比,口服EPL的山羊的心房平滑肌肌动蛋白、Ⅲ型胶原表达

JACC:ABSORB Ⅲ期临床试验3年随访结果出炉——生物可吸收支架远期预后不容乐观

可吸收依维莫司洗脱的聚左旋乳酸生物可吸收支架(BVS)可以提供类似于金属药物洗脱支架(DES)的药物作用和机械支撑。ABSORB第3期临床试验将2008名冠心病患者随机分成BVS组和钴铬合金依维莫司洗脱支架(EES)组,随访1年的结果显示了BVS在靶器官损伤(心源性死亡、靶血管心肌梗死和缺血性靶病变血运重建)的非劣效性。本研究的目的旨在评估BVS植入后3年的患者预后结局。随访3年后,复合主要终点事

JACC:低钠联合DASH饮食能显著改善高血压

减少钠的摄入和DASH(Dietary Approaches to Stop Hypertension)饮食(一种富含水果、蔬菜和低脂产品,而饱和脂肪酸和胆固醇较少的食谱)均有降低血压的功能。然而,这些干预方式对基线血压水平的单独和联合效果尚未阐明。本研究的目的旨在比较评估低钠摄入和高钠摄入、DASH饮食和对照、低钠联合DASH饮食和高钠对照饮食对基线收缩压水平的影响。本研究纳入了高血压前期或1期

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