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Am J Psychiat:荷兰研究称,孕妇抑郁,孩子10岁大脑发育仍受影响

2019-05-21 岱西 中国循环杂志

近期一项荷兰研究就显示,生孩子前后抑郁与10年后孩子大脑发育受影响有关,其中产后是脆弱窗口期。

生而为人,七情六欲难禁,但想要孩子正常,就要求自己得平和正常,尤其是母亲。

近期一项荷兰研究就显示,生孩子前后抑郁与10年后孩子大脑发育受影响有关,其中产后是脆弱窗口期。

轨迹分析发现,生孩子前后长期较为抑郁,其子大脑灰质和白质体积会相对母亲愉悦者变小,此外白质微结构也有改变。

不同时间点进行分析可见,孩子2个月时母亲抑郁影响最为明显,孩子大脑总灰质体积变小,各向异性分数(FA)较低,但产前和儿童期无此变化。

研究显示,母亲简短症状量表(BSI)抑郁评分每增加1分,总灰质体积减少0.96%。那些暴露在母亲BSI评分较高的儿童,总灰质体积减少达3.8%。

而大脑灰质体积的差异介导了母亲抑郁和儿童注意力问题之间的关联。

这项人群为基础的研究,研究者评估了从胎儿期到10岁大脑影像学检查与母亲抑郁症状暴露的关系。其中共纳入3469对母子。

原始出处:Runyu Zou , B.Med, Henning Tiemeier, Jan van der Ende, et al. Exposure to Maternal Depressive Symptoms in Fetal Life or Childhood and Offspring Brain Development: A Population-Based Imaging Study. Am J Psychiat. 2019 May 6

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